Evidence map›Paper›PMID 32732929›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2021

A comparative study of RTK gene status between primary tumors, lymph-node metastases, and Krukenberg tumors.

Bo Wang, Qiusu Tang, Liming Xu, Xiaodong Teng, Wei Ding, Guoping Ren, Xiaoling Wang

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. [Research progress on non-surgical treatment of vestibular schwannomas].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bo WangDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
Qiusu TangDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
Liming XuDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
Xiaodong TengDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
Wei DingDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
Guoping Ren *Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, China. wanglingjane@163.com.
Xiaoling Wang *Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, China. 1307025@zju.edu.cn.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Krukenberg tumor (KT) refers to a rare ovarian tumor that has metastasized from a primary site. Patients with KTs have a poorer prognosis and worse survival. Thus far, little is known about the frequency of receptor tyrosine kinase (RTK) gene amplification and the concordance of gene amplification between primary tumors, lymph-node metastases, and KTs. Herein, 50 paired samples, including primary cancers, metastatic lymph nodes, and KTs were collected, and RTK gene amplification was tested by fluorescence in situ hybridization (FISH). There were four cases positive for human epidermal growth factor receptor type 2 (HER2) amplification, all of which showed conversion of HER2 status between different lesions. Of the two cases with c-mesenchymal-epithelial transition (c-MET) amplification, the primary tumors and lymph nodes were negative while the right involved ovaries were positive. Inconsistent fibroblast growth factor receptor 2 (FGFR2) status in different lesions was observed in three of the six FGFR2-amplified cases. Co-amplification of RTK genes was identified in only one patient for primary cancer and two for KTs. Collectively, there were 46, 48, 50, and 44 cases negative for HER2, c-MET, EGFR, and FGFR2 amplification in all lesions, respectively. There was no significant difference in overall survival between KTs of gastric origin and colorectal origin. However, of all synchronous cancers, KTs of colorectal origin had a better prognosis than those of gastric origin. In conclusion, the positive rate of RTK gene amplification in KTs was low. Intratumoral heterogeneity was frequent in KTs with RTK gene amplification. A mutually exclusive pattern of RTK gene amplification was dominant in primary cancers, lymph-node metastases, and KTs. There was no survival difference between KTs of gastric origin and colorectal origin. However, of all synchronous cancers, KTs of colorectal origin had a better prognosis than those of gastric origin.

Indexed as

AdultAgedColorectal NeoplasmsFemaleGene AmplificationHumansKrukenberg TumorLymphatic MetastasisMiddle AgedOvarian NeoplasmsReceptor Protein-Tyrosine KinasesStomach NeoplasmsReceptor Protein-Tyrosine Kinases

Identifiers

PMID32732929
OpenAlexW3045596449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.