SynthesisTransplantation2020
Long-term Graft Survival and Graft Function Following Pregnancy in Kidney Transplant Recipients: A Systematic Review and Meta-analysis.
Synthesis in Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Psychological Experiences of Pregnancy Following Transplantation: A Systematic Qualitative Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Long-term impact of pregnancy on mortality and graft outcomes in kidney transplant recipients: a systematic review and meta-analysis.International urology and nephrology · 2025Pooled it
- Outcomes and management strategies of pregnancies after heart and lung transplantation across Europe.JHLT open · 2026Article
- Pregnancy after kidney transplantation: global insights based on registry data from three continents.Journal of nephrology · 2025Article
- Pregnancy After Solid Organ Transplantation: Review of the Evidence and Recommendations.Transplantation · 2025Review
- Pregnancy and Delivery After Solid Organ and Uterus Transplantation: A Review.Journal of clinical medicine · 2025Review
- Severe maternal morbidity and risk of transplant rejection in pregnant patients with a history of solid-organ transplant.American journal of obstetrics & gynecology MFM · 2025Article
- Maternal and neonatal outcomes in kidney transplant recipients: a single-center observational study.Wiener klinische Wochenschrift · 2025Observational
- Family planning after transplantation: sex- and organ-related differences in the perception of medical counseling and social challenges.Archives of gynecology and obstetrics · 2025Article
- Maternal, Fetal, and Kidney Outcomes of Viable Pregnancies in Women with Underlying Kidney Disease: Experience from a Single Tertiary Care Center in India.Indian journal of nephrology · 2024Article
- Pregnancy Among Women Receiving Chronic Dialysis in France (2006-2020).Kidney international reports · 2024Article
- Late pregnancy in women with renal transplants: A multidisciplinary guide.Obstetric medicine · 2024Review
- Gender and kidney transplantation.Frontiers in nephrology · 2024Review
- Counselling, Research Gaps, and Ethical Considerations Surrounding Pregnancy in Solid Organ Transplant Recipients.Journal of bioethical inquiry · 2023Article
- Pregnancy after Kidney Transplantation-Impact of Functional Renal Reserve, Slope of eGFR before Pregnancy, and Intensity of Immunosuppression on Kidney Function and Maternal Health.Journal of clinical medicine · 2023Article
- Counselling on Conceiving: Attitudes and Factors Influencing Advice of Professionals in Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Successful pregnancies in post-kidney transplant couples: four case reports.Frontiers in immunology · 2023Article
- Pregnancy after kidney transplantation: an observational study on maternal, graft and offspring outcomes in view of current literature.Frontiers in nephrology · 2023Article
- Sex-specific time trends of long-term graft survival after kidney transplantation - a registry-based study.Renal failure · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of pregnancy in kidney transplantation (KT) recipients is increasing. Studies report that the incidence of graft loss (GL) during pregnancy is low, but less data are available on long-term effects of pregnancy on the graft.
methodsTherefore, we performed a meta-analysis and systematic review on GL and graft function, measured by serum creatinine (SCr), after pregnancy in KT recipients, stratified in years postpartum. Furthermore, we included studies of nulliparous KT recipients.
resultsOur search yielded 38 studies on GL and 18 studies on SCr. The pooled incidence of GL was 9.4% within 2 years after pregnancy, 9.2% within 2-5 years, 22.3% within 5-10 years, and 38.5% >10 years postpartum. In addition, our data show that, in case of graft survival, SCr remains stable over the years. Only within 2 years postpartum, Δ SCr was marginally higher (0.18 mg/dL, 95%CI [0.05-0.32], P = 0.01). Furthermore, no differences in GL were observed in 10 studies comparing GL after pregnancy with nulliparous controls. Systematic review of the literature showed that mainly prepregnancy proteinuria, hypertension, and high SCr are risk factors for GL.
conclusionsOverall, these data show that pregnancy after KT has no effect on long-term graft survival and only a possible effect on graft function within 2 years postpartum. This might be due to publication bias. No significant differences were observed between pre- and postpartum SCr at longer follow-up intervals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.