Evidence map›Paper›PMID 32732435›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens.

Yifan Wang, Kathy Fange Liu, Yu Yang, Ian Davis, Aimin Liu

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Mimicking Extradiol Dioxygenase Reactivity on Iridium.Journal of the American Chemical Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yifan WangDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249.ORCID 0000-0003-0378-2469
Kathy Fange LiuDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Yu YangDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249.
Ian DavisDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249.ORCID 0000-0002-1566-4972
Aimin LiuDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249; feradical@utsa.edu.ORCID 0000-0002-4182-8176
The University of Texas at San Antonio · USUniversity of Pennsylvania · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Heme-dependent chemistry in tyrosine oxidation: Diversity Supplement on 5R01GM108988-08 for supporting Samuel MontoyaR01GM108988 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI LIU, AIMIN · 2014 to 2025
$4.2M
Coregulation of mRNA, tRNA, and rRNA species through RNA modificationsR35GM133721 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LIU, FANGE · 2019 to 2023
$2.5M
Kynurenine metabolites and depression: An in vitro and ex vivo studyR21MH107985 · NIMH · UNIVERSITY OF TEXAS SAN ANTONIO · PI LIU, AIMIN, SHAMSI, SHAHAB AHMED · 2016 to 2017
$420k
NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM108988NIGMS NIH HHS R35 GM133721NIMH NIH HHS R21 MH107985
6 · The paper itself

Abstract

The synthesis of quinolinic acid from tryptophan is a critical step in the de novo biosynthesis of nicotinamide adenine dinucleotide (NAD

Indexed as

3-Hydroxyanthranilate 3,4-DioxygenaseAnimalsBacterial ProteinsCatalytic DomainCrystallizationCrystallography, X-RayCupriavidusKineticsLactonesModels, MolecularSubstrate Specificity3-Hydroxyanthranilate 3,4-DioxygenaseBacterial ProteinsLactoneskynurenine pathwaymechanistic enzymologymetalloproteinNAD biosynthesisoxygen activation

Identifiers

PMID32732435
PMCPMC7443976
OpenAlexW3046598119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.