Evidence map›Paper›PMID 32732300›Full record

ArticleNeurology2020

Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory.

Ji Won Han, Pauline Maillard, Danielle Harvey, Evan Fletcher, Oliver Martinez, David K Johnson, John M Olichney, Sarah T Farias, Sylvia Villeneuve, William Jagust and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
  7. The role of the intestinal microbiome in cognitive decline in patients with kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  8. Racial and ethnic differences in white matter hypointensities: The role of vascular risk factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 3 countries.

Ji Won HanFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.ORCID 0000-0003-2418-4257
Pauline MaillardFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.ORCID 0000-0003-3516-6345
Danielle HarveyFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.
Evan FletcherFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.
Oliver MartinezFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.
David K JohnsonFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.ORCID 0000-0003-3670-8054
John M OlichneyFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.
Sarah T FariasFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.
Sylvia VilleneuveFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.ORCID 0000-0003-2338-0467
William JagustFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.
Dan MungasFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley.
Charles DeCarliFrom the Department of Neurology (J.W.H., P.M., E.F., O.M., D.K.J., J.M.O., S.T.F., D.M., C.D.), Imaging of Dementia and Aging (IDeA) Laboratory (J.W.H., P.M., E.F., O.M., C.D.), and Division of Biostatistics, School of Medicine (D.H.), University of California at Davis; Department of Neuropsychiatry (J.W.H.), Seoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea; Douglas Mental Health University Institute (S.V.), McGill University, Montreal, Canada; and Helen Wills Neuroscience Institute (W.J.), University of California, Berkeley. cdecarli@ucdavis.edu.
Neurosciences Institute · US

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
The impact of non-amyloid processes on cognitive agingR01AG047827 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES · 2014 to 2018
$2.9M
NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG031563NIA NIH HHS R01 AG047827NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

objectiveTo determine whether vascular and neurodegenerative factors influence cognition before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and amyloid imaging in an ethnoracially diverse cohort of cognitively normal individuals older than 60 years.

methodsParticipants (n = 154; mean age 74.15 ± 6.94; 50% female; 54% Caucasian, 22.1% Hispanic, 14.9% African American) were recruited from the University of California, Davis Alzheimer's Disease Research Center, who were cognitively normal at baseline, time of PET, and MRI, and received yearly cognitive assessment for 6.23 ± 4.16 years. Mixed model regression with random slope and intercept was calculated for episodic memory and executive function, adjusting for age, sex, education, and ethnicity.

resultsVascular burden score was associated with total white matter hyperintensity (WMH) volume (β, 0.171; 95% confidence interval [CI], 0.024-0.318). WMH volume was associated with low baseline executive function (-0.115; -0.226 to -0.003) and rate of change in memory (-0.029; -0.045 to -0.012). Hippocampal volume was associated with the rate of change in memory (0.040; 0.021-0.059) and executive function (0.024; 0.008-0.039). Continuous measures of amyloid status influenced change in memory (-0.026; -0.044 to -0.008) and executive function (-0.033; -0.046 to -0.021) independently of MRI measures.

conclusionVascular brain injury and neurodegeneration are associated with baseline cognitive performance and the rate of longitudinal change independent of amyloid status among community-dwelling, ethnicity diverse cognitively normal individuals, supporting the role of vascular diseases as risk factors for later-life dementia.

Indexed as

AgedAged, 80 and overAmyloid beta-PeptidesAniline CompoundsBrainCerebrovascular DisordersCognitionCognitive DysfunctionDisease ProgressionExecutive FunctionFemaleHippocampusHumansIndependent LivingMagnetic Resonance ImagingMale2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsThiazoles

Identifiers

PMID32732300
PMCPMC7713731
OpenAlexW3045649192

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.