ArticleNeurology2020
Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults.
Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Timing of orthostatic hypotension and its relationship with falls in older adults.Journal of the American Geriatrics Society · 2023Trial
- Dizziness in older persons at high risk of future hospitalization: prevalence, differences between those with and without dizziness, and effect of a proactive primary care intervention.BMC geriatrics · 2022Trial
- Effects of Antihypertensive Deprescribing Strategies on Blood Pressure, Adverse Events, and Orthostatic Symptoms in Older Adults: Results From TONE.American journal of hypertension · 2022Trial
- Effects of Vitamin D Supplementation on Orthostatic Hypotension: Results From the STURDY Trial.American journal of hypertension · 2022Trial
- The Association of Orthostatic Hypotension With Ambulatory Blood Pressure Phenotypes in SPRINT.American journal of hypertension · 2021Trial
- Symptoms are an optimal target for orthostatic hypotension screening and management: an argument in favor.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Review
- Cerebral hemodynamic changes and their effects on cognitive function in patients with Parkinson's disease complicated with orthostatic hypotension.Clinical parkinsonism & related disorders · 2026Article
- Multi-omics study of molecular and genetic bases of orthostatic hypotension.Clinical epigenetics · 2025Article
- Cardiovascular Outcomes in Initial and Sustained Orthostatic Hypotension: A Retrospective Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Differential diagnosis of orthostatic dizziness with persistent postural-perceptual dizziness and its underlying mechanisms.Frontiers in neurology · 2025Review
- Exploring the dark side of diagnostic dyes with a focus on Indocyanine green's adverse reactions.Scientific reports · 2024Article
- Orthostatic Hypotension in Adults With Hypertension: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study.CNS neuroscience & therapeutics · 2024Article
- Orthostatic Blood Pressure Change, Dizziness, and Risk of Dementia in the ARIC Study.Hypertension (Dallas, Tex. : 1979) · 2024Article
- The Association of Measures of Cardiovascular Autonomic Function, Heart Rate, and Orthostatic Hypotension With Incident Glucose Disorders: The Cardiovascular Health Study.Diabetes care · 2022Article
- Diagnosis and treatment of orthostatic hypotension.The Lancet. Neurology · 2022Review
- Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels.Annals of clinical and translational neurology · 2022Article
- Systemic and cerebral circulatory adjustment within the first 60 s after active standing: An integrative physiological view.Autonomic neuroscience : basic & clinical · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that orthostatic hypotension (OH) might cause cerebral hypoperfusion and injury, we examined the longitudinal relationship between OH or orthostatic symptoms and incident neurologic outcomes in a community population of older adults.
methodsCardiovascular Health Study participants (≥65 years) without dementia or stroke had blood pressure (BP) measured after lying down for 20 minutes and after standing 3 for minutes. Participants reported dizziness immediately upon standing and any dizziness in the past 2 weeks. OH was defined as a drop in standing systolic/diastolic BP ≥20/≥10 mm Hg. We determined the association between OH or dizziness with (1) MRI brain findings (ventricular size, white matter hyperintensities, brain infarcts) using linear or logistic regression, (2) cognitive function (baseline and over time) using generalized estimating equations, and (3) prospective adjudicated events (dementia, stroke, death) using Cox models. Models were adjusted for demographic characteristics and OH risk factors. We used multiple imputation to account for missing OH or dizziness (n = 534).
resultsPrior to imputation, there were 5,007 participants (mean age 72.7 ± 5.5 years, 57.6% women, 10.9% Black, 16% with OH). OH was modestly associated with death (hazard ratio [HR] 1.11; 95% confidence interval 1.02-1.20), but not MRI findings, cognition, dementia, or stroke. In contrast, dizziness upon standing was associated with lower baseline cognition (β = -1.20; -1.94 to -0.47), incident dementia (HR 1.32; 1.04-1.62), incident stroke (HR 1.22; 1.06-1.41), and death (HR 1.13; 1.06-1.21). Similarly, dizziness over the past 2 weeks was associated with higher white matter grade (β = 0.16; 0.03-0.30), brain infarcts (OR 1.31; 1.06-1.63), lower baseline cognition (β = -1.18; -2.01 to -0.34), and death (HR 1.13; 1.04-1.22).
conclusionsDizziness was more consistently associated with neurologic outcomes than OH 3 minutes after standing. Delayed OH assessments may miss pathologic information related to cerebral injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.