Evidence map›Paper›PMID 32732266›Full record

ArticleAJNR. American journal of neuroradiology2020

Characterizing White Matter Tract Organization in Polymicrogyria and Lissencephaly: A Multifiber Diffusion MRI Modeling and Tractography Study.

F Arrigoni, D Peruzzo, S Mandelstam, G Amorosino, D Redaelli, R Romaniello, R Leventer, R Borgatti, M Seal, J Y-M Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

F ArrigoniFrom the Scientific Institute, IRCCS E. Medea (F.A., D.P., G.A., D.R., R.R.), Bosisio Parini, Italy filippo.arrigoni@lanostrafamiglia.it.ORCID 0000-0002-5508-1149
D PeruzzoFrom the Scientific Institute, IRCCS E. Medea (F.A., D.P., G.A., D.R., R.R.), Bosisio Parini, Italy.ORCID 0000-0002-9480-379X
S MandelstamMurdoch Children's Research Institute (S.M., R.L., M.S., J.Y.-M.Y.), Parkville, Australia.ORCID 0000-0001-6287-0819
G AmorosinoFrom the Scientific Institute, IRCCS E. Medea (F.A., D.P., G.A., D.R., R.R.), Bosisio Parini, Italy.ORCID 0000-0003-2789-5193
D RedaelliFrom the Scientific Institute, IRCCS E. Medea (F.A., D.P., G.A., D.R., R.R.), Bosisio Parini, Italy.ORCID 0000-0002-2926-6254
R RomanielloFrom the Scientific Institute, IRCCS E. Medea (F.A., D.P., G.A., D.R., R.R.), Bosisio Parini, Italy.ORCID 0000-0002-8709-6732
R LeventerMurdoch Children's Research Institute (S.M., R.L., M.S., J.Y.-M.Y.), Parkville, Australia.ORCID 0000-0003-0362-5607
R BorgattiIstituto di ricovero e cura a carattere scientifico Mondino Foundation (R.B.), Pavia, Italy.ORCID 0000-0001-8165-4994
M SealMurdoch Children's Research Institute (S.M., R.L., M.S., J.Y.-M.Y.), Parkville, Australia.ORCID 0000-0002-8396-140X
J Y-M YangMurdoch Children's Research Institute (S.M., R.L., M.S., J.Y.-M.Y.), Parkville, Australia.ORCID 0000-0003-4081-7157
IRCCS Eugenio Medea · ITRoyal Children's Hospital · AUThe University of Melbourne · AUUniversity of Pavia · ITUniversity of Trento · IT

Funding

MRI STUDY OF NORMAL BRAIN DEVELOPMENT CLINICAL COORDINATING CENTER-275023343N01HD023343 · NICHD · WASHINGTON UNIVERSITY · PI BOTTERON, KELLY · 2006 to 2006
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NICHD NIH HHS N01 HD023343
6 · The paper itself

Abstract

background and purposePolymicrogyria and lissencephaly may be associated with abnormal organization of the undelying white matter tracts that have been rarely investigated so far. Our aim was to characterize white matter tract organization in polymicrogyria and lissencephaly using constrained spherical deconvolution, a multifiber diffusion MR imaging modeling technique for white matter tractography reconstruction. MATERIALS AND

methodsWe retrospectively reviewed 50 patients (mean age, 8.3 ± 5.4 years; range, 1.4-21.2 years; 27 males) with different polymicrogyria (

resultsMore abnormal-appearing white matter tracts were identified in patients with lissencephaly compared with those with polymicrogyria (79.2% versus 37.3%). In lissencephaly, structural abnormalities were identified in all studied white matter tracts. In polymicrogyria, the more frequently affected white matter tracts were the cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, and optic radiation-posterior corona radiata. The severity of superior longitudinal fasciculus and cingulum abnormalities was associated with the polymicrogyria distribution and extent. A thickened superior fronto-occipital fasciculus was demonstrated in 3 patients.

conclusionsWe demonstrated a range of white matter tract structural abnormalities in patients with polymicrogyria and lissencephaly. The patterns of white matter tract involvement are related to polymicrogyria and lissencephaly subgroups, distribution, and, possibly, their underlying etiologies.

Indexed as

AdolescentBrainChildChild, PreschoolDiffusion Tensor ImagingFemaleHumansInfantLissencephalyMalePolymicrogyriaRetrospective StudiesWhite MatterYoung Adult

Identifiers

PMID32732266
PMCPMC7658898
OpenAlexW3046720174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.