ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020
Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
36 authors at 20 institutions in 14 countries.
Renée T FortnerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. r.fortner@dkfz-heidelberg.de lj.schouten@maastrichtuniversity.nl.ORCID 0000-0002-1426-8505
Megan S RiceClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Synnove F KnutsenSchool of Public Health, Loma Linda University, Loma Linda, California.
Michael J OrlichSchool of Public Health, Loma Linda University, Loma Linda, California.ORCID 0000-0001-7761-0622
Kala VisvanathanJohns Hopkins Bloomberg School of Public Health and School of Medicine, Baltimore, Maryland.
Alpa V PatelBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Mia M GaudetBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.ORCID 0000-0002-6429-4007
Anne TjønnelandDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4385-2097
Marina KvaskoffCESP, Fac. de médecine-Univ. Paris-Sud, Fac. de médecine-UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.ORCID 0000-0002-4557-3772
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Antonia TrichopolouHellenic Health Foundation, Athens, Greece.
Valeria PalaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID 0000-0001-5438-970X
N Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-2360-913X
Inger T GramDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0002-0031-4152
Pilar AmianoPublic Health División of Gipuzkoa, BioDonostia Research Institute, San-Sebastian-Donostia, Spain.
Annika IdahlDepartment of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.ORCID 0000-0002-7865-4560
Naomi E AllenNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1938-5038
Elisabete WeiderpassInternational Agency for Research on Cancer, Lyon, France.ORCID 0000-0003-2237-0128
Jenny N PoynterDivision of Pediatric Epidemiology and Clinical Research, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-8460-3938
Kim RobienDepartment of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC.ORCID 0000-0002-2120-2280
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0003-4946-9099
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0001-5764-7268
Veronica W SetiawanUniversity of Southern California, Los Angeles, California.
Melissa A MerrittCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Piet A van den BrandtDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.ORCID 0000-0001-8781-8099
Anne Zeleniuch-JacquotteNew York University School of Medicine, New York, New York.
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina.ORCID 0000-0002-1931-1349
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina.ORCID 0000-0002-6776-0018
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Niclas HåkanssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Holly R HarrisProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-2572-6727
Britton TrabertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Washington, DC.ORCID 0000-0002-1539-6090
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Washington, DC.
Shelley S Tworoger *Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-6986-7046
Leo J Schouten *Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands. r.fortner@dkfz-heidelberg.de lj.schouten@maastrichtuniversity.nl.ORCID 0000-0003-3361-7560
American Cancer Society · USGerman Cancer Research Center · DELoma Linda University · USMaastricht University · NLNational Cancer Institute · UANational Institute of Environmental Health Sciences · USNew York University · USThe University of Melbourne · AUBiogipuzkoa Health Research Institute · ESCancer Center of Hawaii · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZACentre international de recherche sur le cancer · FRFondazione IRCCS Istituto Nazionale dei Tumori · ITHarvard University · USHellenic Health Foundation · GRJohns Hopkins University · USKarolinska Institutet · SEMassachusetts General Hospital · USMilken Institute · USUiT The Arctic University of Norway · NO
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Lee Ellen Buenconsejo-Lum, Jerris Robert Hedges · 2017 to 2026
$59.5M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
PLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
Understanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3M
HORMONE-RELATED CANCERSZ01CP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI BRINTON, LOUISE · 1996 to 2008
$11.2M
Cancer Research UK 14136Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Intramural NIH HHS Z01 CP010126Intramural NIH HHS Z01 ES044005Medical Research Council 1000143Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA067262NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA182934NCI NIH HHS UM1 CA186107NIEHS NIH HHS P30 ES000260NIMHD NIH HHS U54 MD007601World Health Organization 001
6 · The paper itself
Abstract
backgroundEpithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites.
methodsWe identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests.
resultsMost associations did not vary by tumor site (
conclusionsOvarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. IMPACT: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium. · full record | OpenQuestion