ArticleSleep health2021
Stress, sleep, and autonomic function in healthy adolescent girls and boys: Findings from the NCANDA study.
Article in Sleep health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Sex differences in electrical activity of the brain during sleep: a systematic review of electroencephalographic findings across the human lifespan.Biomedical engineering online · 2025Pooled it
- Article
- Physical Activity Habits and Sleep Duration According to Gender: A Cross-Sectional Study of Elementary School Children.Healthcare (Basel, Switzerland) · 2024Article
- Stress, hypothalamic pituitary adrenal axis activity and autonomic nervous system function in adolescents with insomnia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Bright Morning Lighting Enhancing Parasympathetic Activity at Night: A Pilot Study on Elderly Female Patients with Dementia without a Pacemaker.Healthcare (Basel, Switzerland) · 2023Article
- Clinical characterization of insomnia in adolescents - an integrated approach to psychopathology.Sleep medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 3 countries.
Funding
Abstract
objectivesStarting in adolescence, female sex is a strong risk factor for the development of insomnia. Reasons for this are unclear but could involve altered stress reactivity and/or autonomic nervous system (ANS) dysregulation, which are strongly associated with the pathophysiology of insomnia. We investigated sex differences in the effect of stress on sleep and ANS activity in adolescents, using the first night in the laboratory as an experimental sleep-related stressor.
designRepeated measures (first night vs. a subsequent night) with age (older/younger) and sex (males/females) as between factors.
settingRecordings were performed at the human sleep laboratory at SRI International.
participantsOne hundred six healthy adolescents (Age, mean ± SD: 15.2 ± 2.0 years; 57 boys). MEASURES: Polysomnographic sleep, nocturnal heart rate (HR), and frequency-domain spectral ANS HR variability (HRV) indices.
resultsBoys and girls showed a first-night effect, characterized by lower sleep efficiency, lower %N1 and %N2 sleep, more wake after sleep onset and %N3 sleep, altered sleep microstructure (increased high-frequency sigma and Beta1 electroencephalographic activity), and reduced vagal activity (P < .05) on the first laboratory night compared to a subsequent night. The first night ANS stress effect (increases in HR and suppression in vagal HRV during rapid eye movement sleep) was greater in girls than boys (P < .05).
conclusionsSleep and ANS activity were altered during the first laboratory night in adolescents, with girls exhibiting greater ANS alterations than boys. Findings suggest that girls may be more vulnerable than boys to sleep-specific stressors, which could contribute to their increased risk for developing stress-related sleep disturbances.
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