Evidence map›Paper›PMID 32731841›Full record

Trial reportUnited European gastroenterology journal2020

Colon capsule endoscopy versus CT colonography after incomplete colonoscopy. Application of artificial intelligence algorithms to identify complete colonic investigations.

U Deding, J Herp, A-L Havshoei, M Kobaek-Larsen, M M Buijs, E S Nadimi, G Baatrup

Registry-linked trialOpen access · bronzeAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02826993 (Can Colon Capsule Endoscopy Substitute CT Colonography in the Large Bowel Examination of Persons Whose Colonoscopy Was Incomplete?), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02826993 nacompletednot on this map

Can Colon Capsule Endoscopy Substitute CT Colonography in the Large Bowel Examination of Persons Whose Colonoscopy Was Incomplete?

TypeinterventionalSponsorOdense University HospitalRan2016 to 2019Enrolled100ConditionsIncomplete Colonoscopy, CT Colonography, Camera Capsule EndoscopyArmsCCE in incomplete Colonoscopies
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  15. Change in onset age of first primary colorectal cancer in the USA.International journal of colorectal disease · 2023
    Article
  16. Clinical utility of colon capsule endoscopy: a moving target?Therapeutic advances in gastroenterology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

U DedingDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-8263-2989
J HerpApplied AI and Data Science Group, Mærsk-Mc-Kinney Møller Institute, Faculty of Engineering, University of Southern Denmark, Odense, Denmark.
A-L HavshoeiDepartment of Surgery, Odense University Hospital, Odense, Denmark.
M Kobaek-LarsenDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
M M BuijsDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-7206-0713
E S NadimiApplied AI and Data Science Group, Mærsk-Mc-Kinney Møller Institute, Faculty of Engineering, University of Southern Denmark, Odense, Denmark.
G BaatrupDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
University of Southern Denmark · DKOdense University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGuidelines suggest computed tomography colonography (CTC) following incomplete optical colonoscopy (OC). Colon capsule endoscopies (CCE) have been suggested as an alternative, although completion rates have been unsatisfactory. Introduction of artificial intelligence (AI)-based localization algorithms of the camera capsules may enable identification of incomplete CCE investigations overlapping with incomplete OCs.

objectiveThe study aims to investigate relative sensitivity of CCE compared with CTC following incomplete OC, investigate the completion rate when combining results from the incomplete OC and CCE, and develop a forward-tracking algorithm ensuring a safe completeness of combined investigations.

methodsIn this prospective paired study, patients with indication for CTC following incomplete OC were included for CCE and CTC. Location of CCE abortion and OC abortion were registered to identify complete combined investigations. AI-based algorithm for localization of capsules were developed reconstructing the passage of the colon.

resultsIn 237 individuals with CTC indication; 105 were included, of which 97 underwent both a CCE and CTC. CCE was complete in 66 (68%). Including CCEs which reached most oral point of incomplete OC, 73 (75%) had complete colonic investigations; 78 (80%) had conclusive investigations. Relative sensitivity of CCE compared with CTC was 2.67 (95% confidence interval (CI) 1.76;4.04) for polyps >5 mm and 1.91 (95% CI 1.18;3.09) for polyps >9 mm. An AI-based algorithm was developed.

conclusionSensitivity of CCE following incomplete OC was superior to CTC. Introducing and improving algorithm-based localization of capsule abortion may increase identification of overall complete investigation rates following incomplete OC.ClinicalTrials.gov identifier: NCT02826993.

Indexed as

Artificial IntelligenceAgedCapsule EndoscopyColonColonic PolypsColonography, Computed TomographicColonoscopyColorectal NeoplasmsEarly Detection of CancerFemaleHumansImage Processing, Computer-AssistedIntestinal MucosaMaleMiddle AgedProspective Studiesartificial intelligencecamera capsule endoscopycolon cancerColon capsule endoscopycolonoscopycolorectal cancercomputed tomography colonographyCT colonographyendoscopyoptical colonoscopy

Identifiers

PMID32731841
PMCPMC7435000
OpenAlexW3047364608

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.