Evidence map›Paper›PMID 32731627›Full record

ArticleMolecules (Basel, Switzerland)2020

l-Malate (-2) Protonation State is Required for Efficient Decarboxylation to l-Lactate by the Malolactic Enzyme of

Waldo Acevedo, Pablo Cañón, Felipe Gómez-Alvear, Jaime Huerta, Daniel Aguayo, Eduardo Agosin

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. GlnR positively affects the acid resistance ofFrontiers in microbiology · 2025
    Article
  3. Review
  4. Article
  5. Metabolic behavior for a mutantFrontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Waldo AcevedoInstitute of Chemistry, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso 2373223, Chile.ORCID 0000-0002-1182-0253
Pablo CañónDepartment of Chemical and Bioprocess Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Santiago 7810000, Chile.
Felipe Gómez-AlvearCenter for Bioinformatics and Integrative Biology (CBIB), Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago 8370146, Chile.
Jaime HuertaCenter for Bioinformatics and Integrative Biology (CBIB), Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago 8370146, Chile.
Daniel AguayoCenter for Bioinformatics and Integrative Biology (CBIB), Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago 8370146, Chile.
Eduardo AgosinDepartment of Chemical and Bioprocess Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Santiago 7810000, Chile.
Universidad Andrés Bello · CLPontificia Universidad Católica de Chile · CLPontificia Universidad Católica de Valparaíso · CL

Funding

Comisión Nacional de Investigación Científica y Tecnológica 21121015Comisión Nacional de Investigación Científica y Tecnológica 21130688Fondequip EQM140174 P09-022-FFondo Nacional de Desarrollo Científico y Tecnológico 1171654
6 · The paper itself

Abstract

Malolactic fermentation (MLF) is responsible for the decarboxylation of l-malic into lactic acid in most red wines and some white wines. It reduces the acidity of wine, improves flavor complexity and microbiological stability. Despite its industrial interest, the MLF mechanism is not fully understood. The objective of this study was to provide new insights into the role of pH on the binding of malic acid to the malolactic enzyme (MLE) of

Indexed as

Bacterial ProteinsLactic AcidMalate DehydrogenaseMalatesOenococcusBacterial ProteinsLactic AcidMalate DehydrogenaseMalatesmalic acidmalolactic enzymedockingisothermal titration calorimetrymalolactic enzymemolecular dynamicsreaction mechanism

Identifiers

PMID32731627
PMCPMC7435853
OpenAlexW3046015429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.