Evidence map›Paper›PMID 32731485›Full record

ArticleNutrients2020

A Pilot Study Examining Vitamin C Levels in Periodontal Patients.

Molly-Rose Munday, Rohan Rodricks, Michael Fitzpatrick, Victoria M Flood, Jenny E Gunton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Molly-Rose MundayWestmead Hospital, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2145, Australia.
Rohan RodricksDepartment of Oral Restorative Sciences (Periodontics), Westmead Centre for Oral Health, Westmead, NSW 2145, Australia.ORCID 0000-0002-7130-8745
Michael FitzpatrickNSW Health Pathology, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
Victoria M FloodSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0001-5310-7221
Jenny E GuntonWestmead Hospital, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2145, Australia.ORCID 0000-0002-8127-9773
The University of Sydney · AURoyal Prince Alfred Hospital · AUWestmead Institute · AU

Funding

National Health and Medical Research Council APPID 1149976
6 · The paper itself

Abstract

backgroundPeriodontal disease is the leading cause of tooth loss worldwide. Current periodontal treatment is limited by its dependency on patients learning and maintaining good dental habits, and repeated visits to oral health physicians. Vitamin C's role in collagen synthesis and immune function makes it important in wound healing and possibly periodontal healing. Therefore, if some patients are deficient, this may worsen patient outcomes.

methodsPatients were invited to participate following assessment and treatment at the Westmead Centre of Oral Health Periodontic Clinic, regardless of current disease stage or treatment. Adults were eligible if they gave informed consent and had current periodontal disease. Study involvement consisted of periodontal assessment and care followed by an interview and measurement of serum vitamin C and C-reactive protein (CRP).

resultsA total of 6 out of 20 patients had vitamin C levels less than the institutional normal range, of whom 2 had levels <11.4 μmol/L and one <28 μmol/L. Low vitamin C was associated with higher periodontal disease stage (

conclusionAlthough a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. This warrants further studies to assess vitamin C and whether supplementation improves periodontal outcomes, particularly in deficient subjects.

Indexed as

AgedAscorbic AcidAscorbic Acid DeficiencyAustraliaC-Reactive ProteinFemaleHumansMaleMiddle AgedNutritional StatusPeriodontal DiseasesPilot ProjectsPrevalenceAscorbic AcidC-Reactive Proteinadult periodontitisascorbic acidgingivitisperiodontal diseasevitamin C deficiencies

Identifiers

PMID32731485
PMCPMC7469055
OpenAlexW3045949311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.