ArticleLife (Basel, Switzerland)2020
The Messy Alkaline Formose Reaction and Its Link to Metabolism.
Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Strands in a Web: Free Energies of Select Prebiotic Reactions with Sugars, Nitriles and Azoles.Life (Basel, Switzerland) · 2026Article
- From searching for extraterrestrial biosignatures to exploring the origins of life: A prebiotic chemistry perspective.Fundamental research · 2026Review
- Low-Molecular-Weight Polyols as Key Factors in Sulfur- and Borate-Mediated Protomembrane Formation Before the RNA World.Membranes · 2026Review
- The Formose Reaction with SOLife (Basel, Switzerland) · 2026Article
- Comprehensive Mapping of Compositional Dynamics in the Formose Reaction Network.Angewandte Chemie (International ed. in English) · 2026Article
- CO-to-sugars conversion from one-pot two-step electro-organocatalytic process.Chemical science · 2025Article
- The Origin of the Feedstock Molecules for Life on the Hadean Earth.Angewandte Chemie (International ed. in English) · 2025Article
- Sugars to Acids via Thioesters: A Computational Study.Life (Basel, Switzerland) · 2025Article
- Cathodic Hydroxide Ions Induce Tetrose Formation during Glycolaldehyde Electroreduction to Alcohols: A Potential COAngewandte Chemie (International ed. in English) · 2025Article
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- The second wave of formose research.BBA advances · 2025Article
- Sulfur Analogs of the Core Formose Cycle: A Free Energy Map.Life (Basel, Switzerland) · 2024Article
- Article
- Alternative Pathways in Astrobiology: Reviewing and Synthesizing Contingency and Non-Biomolecular Origins of Terrestrial and Extraterrestrial Life.Life (Basel, Switzerland) · 2024Review
- Exploring the Core Formose Cycle: Catalysis and Competition.Life (Basel, Switzerland) · 2024Article
- Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu.Nature communications · 2024Article
- The Origin of RNA and the Formose-Ribose-RNA Pathway.International journal of molecular sciences · 2024Review
- Hexose phosphorylation for a non-enzymatic glycolysis and pentose phosphate pathway on early Earth.Scientific reports · 2024Article
- Synthetic applications of the Cannizzaro reaction.Beilstein journal of organic chemistry · 2024Review
- Pioneering role of RNA in the early evolution of life.Genetics and molecular biology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Sugars are essential for the formation of genetic elements such as RNA and as an energy/food source. Thus, the formose reaction, which autocatalytically generates a multitude of sugars from formaldehyde, has been viewed as a potentially important prebiotic source of biomolecules at the origins of life. When analyzing our formose solutions we find that many of the chemical species are simple carboxylic acids, including α-hydroxy acids, associated with metabolism. In this work we posit that the study of the formose reaction, under alkaline conditions and moderate hydrothermal temperatures, should not be solely focused on sugars for genetic materials, but should focus on the origins of metabolism (via metabolic molecules) as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.