Evidence map›Paper›PMID 32731103›Full record

ArticleJournal of critical care2020

Association of triage hypothermia with in-hospital mortality among patients in the emergency department with suspected sepsis.

Sriram Ramgopal, Christopher M Horvat, Mark D Adler

Open access · greenAbstract read
In one paragraph

Article in Journal of critical care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Hypothermic sepsis in time since death estimation - a case report.International journal of legal medicine · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Electroacupuncture at ST36 (Journal of inflammation research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sriram RamgopalDivision of Emergency Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America. Electronic address: sramgopal@luriechildrens.org.
Christopher M HorvatDivision of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America; Division of Health Informatics, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States of America.
Mark D AdlerDivision of Emergency Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Northwestern University · USChildren's Hospital of Pittsburgh · US

Funding

A Learning Health System Approach to Precision Sedation and Analgesia in Critically-Ill ChildrenK23HD099331 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HORVAT, CHRISTOPHER MICHAEL · 2020 to 2024
$810k
NICHD NIH HHS K23 HD099331
6 · The paper itself

Abstract

purposeTo identify if triage hypothermia (<36.0 °C) among emergency department (ED) encounters with sepsis are independently associated with mortality.

methodsWe analyzed data from a multi-stage probability sample survey of visits to United States EDs between 2007 and 2015, using two inclusion approaches: an explicit definition based on diagnosis codes for sepsis and a severe sepsis definition, combining evidence of infection with organ dysfunction. We used multivariable regression to determine an association between hypothermia and in-hospital mortality.

resultsOf 1.2 billion ED encounters (95% confidence interval [CI] 1.0-1.3 billion), 3.1 million (95% CI 2.7-3.5 million) met the explicit sepsis definition; 7.4% (95% CI 75.2-9.7%) had triage hypothermia. The adjusted odds ratio (aOR) for hypothermia for in-hospital mortality was 6.82 (95% CI 3.08-15.22). The severe sepsis definition identified 3.5 million (95% 3.1-4.0 million) encounters; 30.3% (95% CI 25.0-34.6%) had triage hypothermia. The aOR for hypothermia with mortality was 4.08 (95% CI 2.09-7.95). Depending on sepsis definition, 78.1-84.4% had other systemic inflammatory response syndrome vital sign abnormalities.

conclusionUp to one in three patients with sepsis have triage hypothermia, which is independently associated with mortality. 10-20% of patients with hypothermic sepsis do not have other vital sign abnormalities.

Indexed as

Hospital MortalityAdolescentAdultAgedChildChild, PreschoolComorbidityCross-Sectional StudiesEmergency Service, HospitalFemaleHumansHypothermiaInfantInfant, NewbornMaleMiddle AgedEmergency departmentHypothermiaMortalitySepsisSeptic shockSevere sepsis

Identifiers

PMID32731103
PMCPMC7872398
OpenAlexW3042862752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.