ReviewProgress in neuro-psychopharmacology & biological psychiatry2021
The SARS-CoV-2 and mental health: From biological mechanisms to social consequences.
Review in Progress in neuro-psychopharmacology & biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 149 citations in OpenAlex.
- New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic.Scientific reports · 2025Observational
- Performance assessment of disposable carbon-based immunosensors for the detection of SARS-CoV-2 infections.Scientific reports · 2025Article
- Article
- The COVID-19 Pandemic and Emergencies in Otolaryngology-Head and Neck Surgery: An Analysis of Patients Presenting to Emergency Rooms in South-West Germany: A Bi-Center Study.Diseases (Basel, Switzerland) · 2024Article
- Serotonin and schizophrenia: what influences what?Frontiers in psychiatry · 2024Article
- The COVID-19 pandemic: new challenges for the mental health protection system.Postepy psychiatrii neurologii · 2023Review
- Psycho-Cardiological Disease in COVID-19 Era.Reviews in cardiovascular medicine · 2023Review
- Patterns and predictors of depressive and anxiety symptoms within a population-based sample of adults diagnosed with COVID-19 in Michigan.Social psychiatry and psychiatric epidemiology · 2023Article
- A rare clinical presentation after COVID-19: Manic episode with psychotic features.Psychiatry research case reports · 2023Article
- The Role of Telemedicine for Psychological Support for Oncological Patients Who Have Received Radiotherapy.Current oncology (Toronto, Ont.) · 2023Article
- Temporal dynamics in mental health symptoms and loneliness during the COVID-19 pandemic in a longitudinal probability sample: a network analysis.Translational psychiatry · 2023Article
- Suicidal ideation following self-reported COVID-19-like symptoms or serology-confirmed SARS-CoV-2 infection in France: A propensity score weighted analysis from a cohort study.PLoS medicine · 2023Article
- Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses.Bioorganic chemistry · 2023Article
- Association between quarantine and sleep disturbance in Hong Kong adults: The mediating role of COVID-19 mental impact and distress.Frontiers in psychiatry · 2023Article
- Intelligent System for Detecting Deterioration of Life Satisfaction as Tool for Remote Mental-Health Monitoring.Sensors (Basel, Switzerland) · 2022Article
- Impact of COVID-19 on Health-Related Quality of Life: A Longitudinal Study in a Spanish Clinical Sample.International journal of environmental research and public health · 2022Observational
- COVID-19 Lockdown in New Zealand: Perceived Stress and Wellbeing among International Health Students Who Were Essential Frontline Workers.International journal of environmental research and public health · 2022Article
- Reviving the mutual impact of SARS-COV-2 and obesity on patients: From morbidity to mortality.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- The potential impact of Covid-19 on CNS and psychiatric sequels.Asian journal of psychiatry · 2022Article
- Mental health of university students during the pandemic. Threats to their mental health and proposals for university student support in Poland.Postepy psychiatrii neurologii · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In December 2019, the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) infection was reported. In only few weeks it has caused a global pandemic, with mortality reaching 3.4%, mostly due to a severe pneumonia. However, the impact of SARS-CoV-2 virus on the central nervous system (CNS) and mental health outcomes remains unclear. Previous studies have demonstrated the presence of other types of coronaviruses in the brain, especially in the brainstem. There is evidence that the novel coronavirus can penetrate CNS through the olfactory or circulatory route as well as it can have an indirect impact on the brain by causing cytokine storm. There are also first reports of neurological signs in patients infected by the SARS-Cov-2. They show that COVID-19 patients have neurologic manifestations like acute cerebrovascular disease, conscious disturbance, taste and olfactory disturbances. In addition, there are studies showing that certain psychopathological symptoms might appear in infected patients, including those related to mood and psychotic disorders as well as post-traumatic stress disorder. Accumulating evidence also indicates that the pandemic might have a great impact on mental health from the global perspective, with medical workers being particularly vulnerable. In this article, we provide a review of studies investigating the impact of the SARS-CoV-2 on the CNS and mental health outcomes. We describe neurobiology of the virus, highlighting the relevance to mental disorders. Furthermore, this article summarizes the impact of the SARS-CoV-2 from the public health perspective. Finally, we present a critical appraisal of evidence and indicate future directions for studies in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.