ReviewProgress in neurobiology2021
Left and right hemispheric lateralization of the amygdala in pain.
Review in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Functional brain alterations associated with acupuncture for chronic pain: a scoping review of fMRI studies.Frontiers in neuroscience · 2026Pooled it
- Transcutaneous auricular nerve stimulation modulates the functional connectivity of the descending pain modulation system and reward network in patients with chronic low back pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Trial
- Gabapentinoids-duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting.British journal of clinical pharmacology · 2026Review
- Role of PBN-CeA Circuit in Paclitaxel-Induced Neuropathic Pain and Negative Emotions.CNS neuroscience & therapeutics · 2026Article
- Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.Molecular psychiatry · 2026Article
- Targeting the posterior thalamic hub: hemispheric-specific encoding of pain-depression comorbidity after hemorrhagic stroke.BMC medicine · 2026Article
- Right amygdala ablation reduces maladaptive negative interpretation bias and symptoms in a patient with post-traumatic stress disorder.Nature communications · 2026Article
- Sex-dependent central amygdala physiology after supradural CGRP exposure is associated with migraine-like behaviors.The journal of headache and pain · 2026Article
- An expanded cortical map of von Economo neurons in the human medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Age- and sex- dependent effects of moderate gestational day 12 prenatal alcohol exposure on anxiety-like behaviors, ethanol intake, and mechanical sensitivity.bioRxiv : the preprint server for biology · 2026Article
- Acute susceptibility changes of deep gray matter nuclei to gadobutrol: a prospective longitudinal study using quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2026Article
- Sex differences in nucleus accumbens circuitry engaged with binge-like ethanol drinking.Psychopharmacology · 2026Article
- Molecular Signatures of Maladaptive Plasticity in the Amygdala in a Rat Model of Chronic Neuropathic Pain.Cells · 2026Article
- Nociceptive thresholds in broiler chickens are modulated by lameness of their progenitors and sex category.Scientific reports · 2026Article
- Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species.Biological psychiatry · 2026Review
- Amygdalar calcitonin gene-related peptide driven effects of cold sensitivity induced by peripheral neuropathy in mice.The journal of pain · 2026Article
- Neuropeptides in control of left-right neural circuits.Trends in neurosciences · 2026Review
- Article
- Transcranial photobiomodulation with near-infrared laser induces analgesia in rats.The Journal of physiology · 2026Article
- Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hemispheric asymmetries within the brain have been identified across taxa and have been extensively studied since the early 19th century. Here, we discuss lateralization of a brain structure, the amygdala, and how this lateralization is reshaping how we understand the role of the amygdala in pain processing. The amygdala is an almond-shaped, bilateral brain structure located within the limbic system. Historically, the amygdala was known to have a role in the processing of emotions and attaching emotional valence to memories and other experiences. The amygdala has been extensively studied in fear conditioning and affect but recently has been shown to have an important role in processing noxious information and impacting pain. The amygdala is composed of multiple nuclei; of special interest is the central nucleus of the amygdala (CeA). The CeA receives direct nociceptive inputs from the parabrachial nucleus (PBN) through the spino-parabrachio-amygdaloid pathway as well as more highly processed cortical and thalamic input via the lateral and basolateral amygdala. Although the amygdala is a bilateral brain region, most data investigating the amygdala's role in pain have been generated from the right CeA, which has an overwhelmingly pro-nociceptive function across pain models. The left CeA has often been characterized to have no effect on pain modulation, a dampened pro-nociceptive function, or most recently an anti-nociceptive function. This review explores the current literature on CeA lateralization and the hemispheres' respective roles in the processing and modulation of different forms of pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.