Evidence map›Paper›PMID 32730165›Full record

SynthesisCancer biology & therapy2020

Long non-coding RNA (lncRNA) and epithelial-mesenchymal transition (EMT) in colorectal cancer: a systematic review.

Stephen J O'Brien, Campbell Bishop, Jacob Hallion, Casey Fiechter, Katharina Scheurlen, Mason Paas, James Burton, Susan Galandiuk

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer biology & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  10. Epigenomics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Stephen J O'BrienPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.ORCID 0000-0003-2686-0300
Campbell BishopPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
Jacob HallionPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
Casey FiechterPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
Katharina ScheurlenPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
Mason PaasPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
James BurtonPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
Susan GalandiukPrice Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
University of Louisville · US

Funding

University of Louisville Cancer Education ProgramR25CA134283 · NCI · UNIVERSITY OF LOUISVILLE · PI HEIN, DAVID W, KIDD, LA CREIS RENEE · 2011 to 2022
$3.1M
NCI NIH HHS R25 CA134283
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is a leading cause of cancer-related death. Epithelial-mesenchymal transition (EMT) is a major process in tumor metastasis development. This systematic review aims to describe the role of long non-coding RNA (lncRNA) in EMT in CRC.

methodsThe electronic databases, PubMed, Cochrane, and EMBASE, were searched from January1990 to June 2019 to identify studies examining lncRNA and their role in mediating EMT in CRC. Studies examining clinical specimens and/or in vitro experiments were included.

resultsIn 61 identified studies, 54 lncRNAs were increased in CRC compared to normal colorectal epithelium. Increased lncRNA expression was frequently associated with worse survival. Many lncRNAs mediate their effect through competitive endogenous RNA or transcription factor regulation. The ZEB1, 2/E-cadherin, Wnt/β-catenin signaling, and chromatin remodeling pathways are discussed in particular.

conclusionslncRNAs are major regulators of EMT and predictor adverse outcome in CRC patients. Future research must focus on delineating lncRNA function prior to potential clinical use.

Indexed as

Colorectal NeoplasmsEpithelial-Mesenchymal TransitionHumansNeoplasm MetastasisRNA, Long NoncodingRNA, Long Noncodingcolorectal cancerepithelial-mesenchymal transitionLong non-coding RNAmetastasissystematic review

Identifiers

PMID32730165
PMCPMC7515495
OpenAlexW3046478612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.