ArticleGut microbes2020
Dysbiosis in a canine model of human fistulizing Crohn's disease.
Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The emerging role of the gut microbiota in vaccination responses.Gut microbes · 2025Review
- Toward clinically relevant models of complex perianal fistulas: refining preclinical evaluation for exosome-based therapies.Stem cell research & therapy · 2025Article
- Canine perianal fistulas.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Supplementation of a new combination of prebiotic and postbiotic shapes fecal microbiota of old dogs while influencing immune parameters.Scientific reports · 2025Article
- Therapeutic potential of atorvastatin in ischemic stroke: an investigation into its anti-inflammatory effect by targeting the gut-brain axis.Journal of translational medicine · 2025Article
- Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study.World journal of gastroenterology · 2024Article
- Comprehensive profile of the companion animal gut microbiome integrating reference-based and reference-free methods.The ISME journal · 2024Article
- Effects of dietary tryptophan supplementation on rectal temperature, humoral immunity, and cecal microflora composition of heat-stressed broilers.Frontiers in veterinary science · 2023Article
- The Intersection of Human and Veterinary Medicine-A Possible Direction towards the Improvement of Cell Therapy Protocols in the Treatment of Perianal Fistulas.International journal of molecular sciences · 2022Review
- Functional properties of miscanthus fiber and prebiotic blends in extruded canine diets.Journal of animal science · 2022Article
- Effect of Echinacea on gut microbiota of immunosuppressed ducks.Frontiers in microbiology · 2022Article
- Comprehensive Analysis of Gut Microbiota and Fecal Bile Acid Profiles in Children With Biliary Atresia.Frontiers in cellular and infection microbiology · 2022Article
- Insight Into the Potential Value of Gut Microbial Signatures for Prediction of Gestational Anemia.Frontiers in cellular and infection microbiology · 2021Article
- Supplemental selenium source on gut health: insights on fecal microbiome and fermentation products of growing puppies.FEMS microbiology ecology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crohn's disease (CD) is a chronic immune-mediated inflammatory condition caused by the loss of mucosal tolerance toward the commensal microbiota. On average, 29.5% and 42.7% CD patients experience perianal complications at 10 and 20 y after diagnosis, respectively. Perianal CD (pCD) result in high disease burden, diminished quality of life, and elevated health-care costs. Overall pCD are predictors of poor long-term outcomes. Animal models of gut inflammation have failed to fully recapitulate the human manifestations of fistulizing CD. Here, we evaluated dogs with spontaneous canine anal furunculosis (CAF), a disease with clinical similarities to pCD, as a surrogate model for understanding the microbial contribution of human pCD pathophysiology. By comparing the gut microbiomes between dogs suffering from CAF (CAF dogs) and healthy dogs, we show CAF-dog microbiomes are either very dissimilar (dysbiotic) or similar (healthy-like), yet unique, to healthy dog's microbiomes. Compared to healthy or healthy-like CAF microbiomes, dysbiotic CAF microbiomes showed an increased abundance of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.