Evidence map›Paper›PMID 32729942›Full record

ArticleJournal of public health dentistry2020

Blood levels of lead and dental caries in permanent teeth.

Juan F Yepes, Jayme McCormick-Norris, LaQuia A Vinson, George J Eckert, Howard Hu, Yue Wu, Erica C Jansen, Karen E Peterson, Martha M Téllez-Rojo, Esperanza Angeles Martinez Mier

Open access · bronzeAbstract read
In one paragraph

Article in Journal of public health dentistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Juan F YepesDepartment of Pediatric Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA.ORCID 0000-0002-3435-9527
Jayme McCormick-NorrisPediatric dentist in private practice, Terre Haute, IN, USA.
LaQuia A VinsonDepartment of Pediatric Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA.
George J EckertBiostatistics, Indiana University, Bloomington, IN, USA.
Howard HuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, Canada.
Yue WuSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Erica C JansenSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3364-3729
Karen E PetersonSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Martha M Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health in Mexico, Cuernavaca, Mexico.
Esperanza Angeles Martinez MierDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USUniversity of Michigan · USIndiana State University · USIndiana University Bloomington · USNational Institute of Public Health · SIUniversity of Southern California · US

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
VANADIUM AND HUMAN HEALTHP42ES005947 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1992 to 2006
$19.6M
LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMESR01ES007821 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 1998 to 2010
$4.7M
Project 3: Developmental Exposures and Diet: Epigenetics of Metabolic SyndromeP01ES022844 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA, PETERSON, KAREN EILEEN · 2013 to 2018
$3.9M
Prenatal and Childhood Exposure to Fluoride and NeurodevelopmentR01ES021446 · NIEHS · UNIVERSITY OF TORONTO · PI HU, HOWARD, MCLAUGHLIN, JOHN · 2012 to 2018
$2.3M
Binational/Cross-cultural Health Enhancement Center at IUPUINational Institute of Public Health/Ministry of Health of MexicoNIEHS NIH HHS P01 ES022844NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30ES017885NIEHS NIH HHS P42 ES005947NIEHS NIH HHS P42-ES05947NIEHS NIH HHS R01 ES007821NIEHS NIH HHS R01ES007821NIEHS NIH HHS R01 ES021446NIEHS NIH HHS R01ES021446NIEHS/U.S. Environmental Protection Agency P01ES022844/RD83543601
6 · The paper itself

Abstract

objectivesThe purpose of this study was to determine whether there is an association between lead exposure within the ages of 1-4 years and dental caries in the permanent dentition between ages 9-17 among Mexican youth.

methodsData were collected for the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) cohort from a group of 490 children born and reared in Mexico City. Among ages 1-4 years, blood lead levels were measured in micrograms of lead per deciliter of blood (μg/dL) and the presence of caries in adolescence was determined using the International Caries and Detection and Assessment System (ICDAS). The relationship between blood levels of lead and decayed, missing, or filled surfaces (DMFS) was examined using negative binomial regression. Covariates were selected based on previous studies and included age, gender, socioeconomic status, oral hygiene, body mass index, and diet. The nonlinear relationship between lead and DMFS was examined using smoothing splines.

resultsThe mean overall blood lead level (BLL) was 4.83 μg/dL (S.D. of 2.2). The mean overall caries level (DMFS) was 4.1. No statistically significant association was found between early childhood blood lead levels and dental caries in adolescence.

conclusionThis study shows a lack of association between exposure to lead between the ages of 1-4 years of age and dental caries in permanent dentition later in life. Other covariates, such as age and sugar consumption, appeared to play a more prominent role in caries development.

Indexed as

Dental CariesLeadAdolescentChildChild, PreschoolDentition, PermanentDMF IndexHumansInfantMexicoOral HygieneLeadblood lead levelsdental cariesrisk factors

Identifiers

PMID32729942
PMCPMC9974220
OpenAlexW3046771223

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.