ArticleInvestigative ophthalmology & visual science2020
Astigmatic Defocus Leads to Short-Term Changes in Human Choroidal Thickness.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05740904 (Efficacy and Safety of New Defocus Spectacle Lens in Preventing Progression of Myopia Compared With the Conventional Single-vision Spectacle Lens), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of New Defocus Spectacle Lens in Preventing Progression of Myopia Compared With the Conventional Single-vision Spectacle Lens: a Randomized Controlled Trial Among Chinese Children
Who cites it
32 citing papers in PubMed, 38 citations in OpenAlex.
- Short-term effects of distant-image screen and myopic defocus on choroidal thickness in children: a randomized pilot clinical trial.Frontiers in public health · 2026Trial
- Urban-Rural and School-Type Disparities in the Prevalence of Myopia and High Myopia in South India.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Regional choroidal perfusion deficits and vector-based choroidal associations in adolescent astigmatism.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2026Article
- Body Mass Index is Associated With Direction-Specific Increases in With-the-Rule Corneal and Refractive Astigmatism in Schoolchildren.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Characterisation and risk factors of astigmatism among children and adolescents aged 3-20 years in Northwestern China.Journal of global health · 2026Article
- Effect of a longpass filter on myopic defocus-induced changes in axial length and choroid thickness.Frontiers in neuroscience · 2026Article
- Influence of Astigmatism Type on Myopia Progression Among Children Wearing Defocus Incorporated Multiple Segments (DIMS) Spectacle Lenses.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Changes in horizontal and vertical peripheral refraction and their predictive value for myopia control after orthokeratology: a 2-year prospective study.Frontiers in medicine · 2026Article
- Comparison of ocular residual astigmatism between children with clinically significant and non-significant astigmatism.BMC ophthalmology · 2025Article
- The role of astigmatism in myopia development, myopia progression and myopia control.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Review
- The Influence of Highly Aspherical Lenslets on Choroidal Thickness and Axial Length.Journal of clinical medicine · 2025Article
- Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes.Translational vision science & technology · 2025Article
- Ocular biological characteristics of children with myopia and rapid axial length changes treated with spectacles with highly aspherical lenslets.International journal of ophthalmology · 2025Article
- Impact of Astigmatism on Axial Elongation in School-Age Children: A Five-Year Population-Based Study in Tianjin, China.Investigative ophthalmology & visual science · 2024Article
- Peripheral Contrast Reduction Optically Induced by Scattering Lenses Thickens Peripheral Choroid.Translational vision science & technology · 2024Article
- Increase in choroidal thickness after blue light stimulation of the blind spot in young adults.Bioelectronic medicine · 2024Article
- Peripheral Choroidal Response to Localized Defocus Blur: Influence of Native Peripheral Aberrations.Investigative ophthalmology & visual science · 2024Article
- Short-Term Myopic Defocus and Choroidal Thickness in Children and Adults.Investigative ophthalmology & visual science · 2024Article
- Astigmatism and maternal myopia as important factors affecting success rate of DIMS lens treatment.BMJ open ophthalmology · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To examine the choroidal thickness (ChT) response to short-term with-the-rule (WTR) and against-the-rule (ATR) simple myopic astigmatic defocus, with the response to spherical myopic defocus and clear vision used as control conditions. Methods: The left eye of 18 healthy adults aged 28 ± 6 years was exposed to clear vision, +3 D spherical myopic defocus, +3 D × 180 WTR, or +3 D × 90 ATR astigmatic defocus for 60 minutes, over four randomly ordered visits, while their right eye was optimally corrected. The macular ChT was measured with optical coherence tomography along the vertical and horizontal meridians before and after 20, 40, and 60 minutes of defocus. Results: After 60 minutes of defocus, ChT increased by +8 ± 5 µm (P < 0.001) with spherical myopic defocus, but varied with simple myopic astigmatic defocus, depending on the axis of astigmatism (P < 0.001), increasing by +5 ± 6 µm (P = 0.037) with WTR and decreasing by -4 ± 5 µm (P = 0.011) with ATR astigmatic defocus. These changes were similar across the vertical and horizontal meridians (P = 0.22). The ChT changes were greater than the change during the clear vision control condition (-1 ± 4 µm) for WTR (+5 ± 5 µm, P = 0.002) but not ATR (-4 ± 6 µm, P = 0.09) astigmatic defocus. Conclusions: These results provide insights into the human ChT response to short-term astigmatic defocus and highlight a potential difference in the myopiagenic signal associated with the orientation of astigmatic blur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.