ArticleeLife2020
A unified computational model for cortical post-synaptic plasticity.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Multimodal evidence for a mechanistic model of working memory deficits in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Plastic Arbor: A modern simulation framework for synaptic plasticity-From single synapses to networks of morphological neurons.PLoS computational biology · 2026Article
- Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle.Science advances · 2025Article
- Synaptic facilitation and learning of multiplexed neural signals.Frontiers in network physiology · 2025Article
- Evaluation and comparison of methods for neuronal parameter optimization using the Neuroptimus software framework.PLoS computational biology · 2024Article
- Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The plasticity of pyramidal neurons in the behaving brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A voltage-based Event-Timing-Dependent Plasticity rule accounts for LTP subthreshold and suprathreshold for dendritic spikes in CA1 pyramidal neurons.Journal of computational neuroscience · 2024Article
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses.Frontiers in synaptic neuroscience · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Dendritic spine morphology regulates calcium-dependent synaptic weight change.The Journal of general physiology · 2022Article
- Article
- A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex.Nature communications · 2022Article
- The effect of alterations of schizophrenia-associated genes on gamma band oscillations.Schizophrenia (Heidelberg, Germany) · 2022Article
- Microbes, metabolites and (synaptic) malleability, oh my! The effect of the microbiome on synaptic plasticity.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury.Journal of neurodevelopmental disorders · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Signalling pathways leading to post-synaptic plasticity have been examined in many types of experimental studies, but a unified picture on how multiple biochemical pathways collectively shape neocortical plasticity is missing. We built a biochemically detailed model of post-synaptic plasticity describing CaMKII, PKA, and PKC pathways and their contribution to synaptic potentiation or depression. We developed a statistical AMPA-receptor-tetramer model, which permits the estimation of the AMPA-receptor-mediated maximal synaptic conductance based on numbers of GluR1s and GluR2s predicted by the biochemical signalling model. We show that our model reproduces neuromodulator-gated spike-timing-dependent plasticity as observed in the visual cortex and can be fit to data from many cortical areas, uncovering the biochemical contributions of the pathways pinpointed by the underlying experimental studies. Our model explains the dependence of different forms of plasticity on the availability of different proteins and can be used for the study of mental disorder-associated impairments of cortical plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.