Evidence map›Paper›PMID 32729666›Full record

Observational studyJournal of cellular and molecular medicine2020

Circular RNA circ_001842 plays an oncogenic role in renal cell carcinoma by disrupting microRNA-502-5p-mediated inhibition of SLC39A14.

Jiawei Zeng, Qian Feng, Yaodong Wang, Gang Xie, Yuanmeng Li, Yuwei Yang, Jiafu Feng

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  20. Role of Circular RNA in Kidney-Related Diseases.Frontiers in pharmacology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jiawei ZengDepartment of Clinical Laboratory, Mianyang Central Hospital, Mianyang, China.
Qian FengCollege of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yaodong WangDepartment of Urology Surgery, Mianyang Central Hospital, Mianyang, China.
Gang XieDepartment of Pathology, Mianyang Central Hospital, Mianyang, China.
Yuanmeng LiDepartment of Medical Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Yuwei YangDepartment of Clinical Laboratory, Mianyang Central Hospital, Mianyang, China.
Jiafu FengDepartment of Clinical Laboratory, Mianyang Central Hospital, Mianyang, China.ORCID 0000-0001-9176-0432
Mianyang Central Hospital · CNAffiliated Hospital of Southwest Medical University · CNChengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinoma (RCC) is a common urologic malignancy, and up to 30% of RCC patients present with locally advanced or metastatic disease at the time of initial diagnosis. Increasing evidence suggests that circular RNAs (circRNAs) serve as genomic regulatory molecules in various human cancers. Our initial in silico microarray-based analysis identified that circRNA circ_001842 was highly expressed in RCC. Such up-regulation of circ_001842 in RCC was experimentally validated in tissues and cell lines using RT-qPCR. Thereafter, we attempted to identify the role of circ_001842 in the pathogenesis of RCC. Through a series of gain- and loss-of function assays, cell biological functions were examined using colony formation assay, Transwell assay, annexin V-FITC/PI-labelled flow cytometry and scratch test. A high expression of circ_001842 in tissues was observed as associated with poor prognosis of RCC patients. circ_001842 was found to elevate SLC39A14 expression by binding to miR-502-5p, consequently resulting in augmented RCC cell proliferation, migration and invasion, as well as EMT in vitro and tumour growth in vivo. These observations imply the involvement of circ_001842 in RCC pathogenesis through a miR-502-5p-dependent SLC39A14 mechanism, suggesting circ_001842 is a potential target for RCC treatment.

Indexed as

AdultAgedAnimalsCarcinoma, Renal CellCation Transport ProteinsCell LineCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansKidney NeoplasmsMaleMiceMice, NudeMicroRNAsCation Transport ProteinsMicroRNAsMIRN502 microRNA, humanRNA, CircularSLC39A14 protein, humancircular RNA circ_001842microRNA-502-5prenal cell carcinomaSLC39A14

Identifiers

PMID32729666
PMCPMC7520279
OpenAlexW3046447615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.