ArticleAngewandte Chemie (International ed. in English)2020
Hetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Double-Click Strategy Combining CuAAC and (Thia-) Diels-Alder Reactions; Application Toward Peptide Labeling.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Applications of Diels-Alder Chemistry in Biomaterials and Drug Delivery.Macromolecular bioscience · 2024Review
- Responsive Microgels through RAFT-HDA Dynamic Covalent Bonding Chemistry.Molecules (Basel, Switzerland) · 2024Article
- Hetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform.Angewandte Chemie (International ed. in English) · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We introduce the bioconjugation of polymers synthesized by RAFT polymerization, bearing no specific functional end group, by means of hetero-Diels-Alder cycloaddition through their inherent terminal thiocarbonylthio moiety with a diene-modified model protein. Quantitative conjugation occurs over the course of a few hours, at ambient temperature and neutral pH, and in the absence of any catalyst. Our technology platform affords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer chains.
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Registered trials
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