Evidence map›Paper›PMID 32729456›Full record

ArticleParasitology2020

Infection with

Hsin-An Lin, Wu-Chien Chien, Kuo-Yang Huang, Chi-Hsiang Chung, Lih-Chyang Chen, Hsin-Chung Lin, Jong-Long Guo

Abstract read
In one paragraph

Article in Parasitology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Seroprevalence and Risk Factors forResearch and reports in tropical medicine · 2025
    Article
  2. Egress Regulatory Factors: HowPathogens (Basel, Switzerland) · 2023
    Review
  3. Article
  4. From the immune system to mood disorders especially induced byFrontiers in cellular and infection microbiology · 2023
    Review
  5. Medicina (Kaunas, Lithuania) · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsin-An LinDivision of Infection, Department of Medicine, Tri-Service General Hospital SongShan Branch, National Defense Medical Center, No. 131, Jiankang Rd., Songshan District, Taipei City10581, Taiwan.
Wu-Chien ChienSchool of Public Health, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City11490, Taiwan.
Kuo-Yang HuangGraduate Institute of Pathology and Parasitology, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City11490, Taiwan.
Chi-Hsiang ChungSchool of Public Health, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City11490, Taiwan.
Lih-Chyang ChenDepartment of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City252, Taiwan.
Hsin-Chung LinDivision of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City11490, Taiwan.
Jong-Long GuoDepartment of Health Promotion and Health Education, National Taiwan Normal University, No. 162, Section 1, Heping E. Rd., Taipei City106, Taiwan.ORCID 0000-0001-7711-4442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate associations between toxoplasmosis and psychiatric disorders in Taiwan based on the National Health Insurance Research Database, Taiwan (1997-2013). Patients newly diagnosed with toxoplasmosis formed the case group (n = 259), and the control group included propensity-score matched patients without toxoplasmosis (n = 1036). The primary outcome was incidence of psychiatric disorders. Cox proportional hazards regression and stratified analyses were performed to examine risk of developing specific psychiatric disorders between patients with and without toxoplasmosis. Patients with toxoplasmosis had significantly higher incidence of psychiatric disorders than those without toxoplasmosis (P = 0.016). A significant difference was found in numbers of psychiatric disorders between the two groups during 14 years of follow-up (log-rank P < 0.001). Those with toxoplasmosis had significantly higher risk of bipolar disorder [adjusted hazard ratio (aHR = 3.60, 95% confidence interval (CI) = 2.07, 7.26), depression (aHR = 4.94, 95% CI = 2.15, 11.80) and anxiety (aHR = 5.36, 95% CI = 2.98, 25.88), but no significant between-group differences were found for schizophrenia and other psychiatric disorders. In conclusion, the present nationwide population-based analysis revealed that Toxoplasma gondii infection in Taiwan significantly increases the risk for developing bipolar disorder, depression and anxiety, but not for schizophrenia and other psychiatric disorders.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesCohort StudiesFemaleHumansIncidenceMental DisordersMiddle AgedTaiwanToxoplasmaToxoplasmosisYoung AdultAnxietybipolar disorderdepressionschizophreniaToxoplasma gondii

Identifiers

PMID32729456
PMCPMC10317747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.