Evidence map›Paper›PMID 32729197›Full record

ArticleChemMedChem2020

Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening.

Rebecca N Adamek, Paul Ludford, Stephanie M Duggan, Yitzhak Tor, Seth M Cohen

Erratum issuedAbstract read
In one paragraph

Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Isomorphic Fluorescent Nucleosides.Accounts of chemical research · 2024
    Article
  3. Article
  4. Review
  5. A New Variant of Emissive RNA Alphabets.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Rebecca N AdamekDepartment of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Paul LudfordDepartment of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Stephanie M DugganDepartment of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Yitzhak TorDepartment of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.ORCID 0000-0002-5233-2280

Funding

Fluorescent Nucleosides and OligonucleotidesR01GM069773 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TOR, YITZHAK · 2004 to 2020
$5.0M
Metal-binding Isosteres for Influenza Endonuclease Inhibitors and BeyondR01AI149444 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SETH M COHEN · 2020 to 2026
$2.3M
Insight and Optimization of Metalloprotein InhibitorsR01GM098435 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THEODORAKIS, EMMANUEL A · 2011 to 2018
$2.2M
Chemical Biology Interfaces at UC San DiegoT32GM112584 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2015 to 2019
$729k
NIAID NIH HHS R01 AI149444NIGMS NIH HHS R01 GM069773NIGMS NIH HHS R01 GM098435NIGMS NIH HHS T32 GM112584
6 · The paper itself

Abstract

Adenosine deaminase (ADA) is a human mononuclear Zn

Indexed as

Adenosine DeaminaseAdenosine Deaminase InhibitorsDose-Response Relationship, DrugDrug Evaluation, PreclinicalHumansMolecular StructureOxazolesZincAdenosine DeaminaseAdenosine Deaminase InhibitorsOxazolesZincFluorescent ProbesFragment Based Drug DiscoveryHigh Throughput ScreeningMedicinal ChemistryMetalloenzymes

Identifiers

PMID32729197
PMCPMC7815202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.