ArticleMagma (New York, N.Y.)2021
In vitro real-time magnetic resonance imaging for quantification of thrombosis.
Article in Magma (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Molecular-gated MRIMaterials today. Bio · 2026Article
- Protruding Objects in the Membrane Lung Outlet May Increase Thrombogenicity: Fluid Dynamical Insights.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Article
- Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction.Annals of biomedical engineering · 2024Article
- A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth.Biomechanics and modeling in mechanobiology · 2024Article
- Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024Article
- A fibrin enhanced thrombosis model for medical devices operating at low shear regimes or large surface areas.PLoS computational biology · 2022Article
- Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.International journal for numerical methods in biomedical engineering · 2022Article
- An Accelerated Thrombosis Model for Computational Fluid Dynamics Simulations in Rotary Blood Pumps.Cardiovascular engineering and technology · 2022Article
- Review
- Computational Prediction of Thrombosis in Food and Drug Administration's Benchmark Nozzle.Frontiers in physiology · 2022Article
- Mathematical and Computational Modeling of Device-Induced Thrombosis.Current opinion in biomedical engineering · 2021Article
- Refining a numerical model for device-induced thrombosis and investigating the effects of non-Newtonian blood models.Journal of biomechanics · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThrombosis is a leading cause of failure for cardiovascular devices. While computational simulations are a powerful tool to predict thrombosis and evaluate the risk for medical devices, limited experimental data are available to validate the simulations. The aim of the current study is to provide experimental data of a growing thrombus for device-induced thrombosis. MATERIALS AND
methodsThrombosis within a backward-facing step (BFS), or sudden expansion was investigated, using bovine and human blood circulated through the BFS model for 30 min, with a constant inflow rate of 0.76 L/min. Real-time three-dimensional flow-compensated magnetic resonance imaging (MRI), supported with Magnevist, a contrast agent improving thrombus delineation, was applied to quantify thrombus deposition and growth within the model.
resultsThe study showed that the BFS model induced a flow recirculation region, which facilitated thrombosis. By 30 min, in comparison to bovine blood, human blood resulted in smaller thrombus formation, in terms of the length (13.3 ± 0.6 vs. 18.1 ± 1.3 mm), height (2.3 ± 0.1 vs. 2.6 ± 0.04 mm), surface area exposed to blood (0.67 ± 0.03 vs 1.05 ± 0.08 cm
conclusionFor the first time, contrast agent-supported real-time MRI was performed to investigate thrombus deposition and growth within a sudden expansion. This study provides experimental data for device-induced thrombosis, which is valuable for validation of computational thrombosis simulations.
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