Evidence map›Paper›PMID 32729058›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2021

One-pot biosynthesis of silver nanoparticles with potential antimicrobial and antibiofilm efficiency against otitis media-causing pathogens.

Eman A Mustafa, Abd El Gawad Hashem, Hala N Elhifnawi, Hanady G Nada, Rania A Khattab

Abstract read
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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Antibacterial Activity of Clove Essential Oil (Pathogens (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eman A MustafaDrug Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, P.O. Box 29, Cairo, Egypt.
Abd El Gawad HashemMicrobiology and Immunology Department, Faculty of Pharmacy, Cairo University, Kasr Al-Aini, 11562, Cairo, Egypt.
Hala N ElhifnawiDrug Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, P.O. Box 29, Cairo, Egypt.
Hanady G NadaDrug Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, P.O. Box 29, Cairo, Egypt. hanadynada@hotmail.com.ORCID http://orcid.org/0000-0001-6723-9997
Rania A KhattabMicrobiology and Immunology Department, Faculty of Pharmacy, Cairo University, Kasr Al-Aini, 11562, Cairo, Egypt.
Egyptian Atomic Energy Authority · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are increasing demands for biogenic synthesis of silver nanoparticles (AgNPs) due to their unique properties and their numerous applications especially in biomedical field. Direct sunlight irradiation on aqueous garlic extract (AGE) represent fast, applicable, non-toxic, cheap, and ecofriendly method for (AgNPs) synthesis, with potentials to compete multi-drug-resistant (MDR) and biofilm-forming pathogens causing otitis media (OM). The aim of this study was to establish an eco-friendly method for synthesis of AgNPs, using aqueous garlic extract and sunlight, and moreover, detect its potential to inhibit MDR OM microbes. Obtained AgNPs were characterized by UV-visible spectral analysis, TEM, DLS, XRD, and FTIR. The effect of biosynthesized AgNPs on microbial growth, as well as biofilm productivity, was assessed against five resistant OM-causing strains, namely Bacillus cereus, Pseudomonas aeruginosa, Penicillium chrysogenum, Aspergillus niger, and Aspergillus flavus. Kirby-Bauer disc diffusion method was used to assess the inhibitory effect of 100, 50, 25, 12.5, and 6.25 μg/ml of AgNPs compared with tetracycline or nystatin and AGE. Additionally, the effect of 25 μg/ml of AgNPs on biofilm productivity of such strains was qualitatively assessed using Congo red agar (CRA) and TEM used to capture the changes inside the selected strains. The obtained AgNPs showed a highly significant (p value < 0.001) antimicrobial and antibiofilm activities against tested strains. TEM images of Pseudomonas aeruginosa and Aspergillus flavus treated with 25 μg/ml AgNPs showed shrinkage in the cytoplasmic materials and rupture of cell walls.

Indexed as

Anti-Bacterial AgentsAspergillus flavusBiofilmsHumansMetal NanoparticlesMicrobial Sensitivity TestsOtitis MediaPseudomonas aeruginosaSilverAnti-Bacterial AgentsSilverAqueous garlic extractBacillus cereusPenicillium. AspergillusPseudomonas aeruginosaSunlight irradiation

Identifiers

PMID32729058
OpenAlexW3045733905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.