Evidence map›Paper›PMID 32729050›Full record

ArticleJournal of endocrinological investigation2021

Parathyroidectomy slows renal function decline in patients with primary hyperparathyroidism.

C-C Liang, H-C Yeh, Y-C Lo, C-Y Chou, T-H Yen, H-C Tsai, S-P Hsu, C-C Kuo

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

C-C LiangKidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.ORCID http://orcid.org/0000-0003-1853-3502
H-C YehKidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Y-C LoBig Data Center, China Medical University Hospital and China Medical University, Taichung, Taiwan.
C-Y ChouDivision of Nephrology, Asia University Hospital, Taichung, Taiwan.
T-H YenKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
H-C TsaiBig Data Center, China Medical University Hospital and China Medical University, Taichung, Taiwan.
S-P HsuCollege of Medicine, China Medical University, Taichung, Taiwan.
C-C KuoKidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan. chinchik@gmail.com.
China Medical University · TWAsia University · TWChang Gung University · TW

Funding

China Medical University Hospital DMR-109-028
6 · The paper itself

Abstract

purposePrimary hyperparathyroidism has deleterious effects on health and causes nephrolithiasis and osteoporosis. However, it remains unclear whether parathyroidectomy benefits kidney function among patients with primary hyperparathyroidism.

methodsIn this retrospective study, patients with primary hyperparathyroidism receiving parathyroidectomy in a tertiary medical center between 2003 and 2017 were followed up until December 31 2017, death, or requiring renal replacement therapy. Impact of parathyroidectomy on kidney function was examined using longitudinal estimated glomerular filtration rate (eGFR) change scales: single, average, absolute difference, percent change, annual decline rate, and slope. We applied linear mixed-effect model to determine the effect of parathyroidectomy on kidney function.

resultsDuring study period, 167 patients with primary hyperparathyroidism were identified from 498 parathyroidectomized patients, and finally, 27 patients fulfilled our stringent criteria. Median follow-up duration was 1.50 years (interquartile range 1.05-1.81) before surgery and 2.47 years (1.37-6.43) after surgery. Although parathyroidectomy did not affect amount of proteinuria and distribution of eGFR, parathyroidectomy significantly slowed decline rate of eGFR compared with that before surgery (- 1.67 versus - 2.73 mL/min/1.73 m

conclusionsOur study showed that parathyroidectomy slows renal function decline irrespective of age or comorbidities, which offers novel insight into the revision of guidelines for surgical indications in primary hyperparathyroidism. Given small sample size, further large-scale controlled studies are warranted to confirm our findings.

Indexed as

Hyperparathyroidism, PrimaryKidney Function TestsParathyroidectomyRenal InsufficiencyAge FactorsChinaFemaleGlomerular Filtration RateHumansLongitudinal StudiesMaleMiddle AgedPostoperative PeriodProteinuriaRenal Replacement TherapySecondary PreventionEstimated glomerular filtrate rateParathyroidectomyPrimary hyperparathyroidismRenal function

Identifiers

PMID32729050
OpenAlexW3045685885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.