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ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Italian version of the Starkstein Apathy Scale (SAS-I) and a shortened version (SAS-6) to assess "pure apathy" symptoms: normative study on 392 individuals.

Elisabetta Garofalo, Alessandro Iavarone, Sergio Chieffi, Michele Carpinelli Mazzi, Nadia Gamboz, Ferdinando Ivano Ambra, Maria Sannino, Filomena Galeone, Sabrina Esposito, Bruno Ronga and 1 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Psychometrics, diagnostics and usability of Italian tools assessing behavioural and functional outcomes in neurological, geriatric and psychiatric disorders: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  2. Apathy and Depression Impact on Cognitive Decline: Neuropsychological Specificities across Neurodegenerative Diseases.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
    Article
  3. Article
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  6. Evaluation of apathy in non-clinical populations: validation, psychometric properties, and normative data of the Italian version of Apathy-Motivation Index (AMI).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  7. Psychometrics and diagnostics of the Italian version of the Beck Depression Inventory-II (BDI-II) in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elisabetta GarofaloNeurological Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy.
Alessandro IavaroneNeurological Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy. aleiavarone@gmail.com.ORCID https://orcid.org/0000-0002-9596-5811
Sergio ChieffiDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Michele Carpinelli MazziNeurological Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy.
Nadia GambozLaboratory of Experimental Psychology, Suor Orsola Benincasa University, Naples, Italy.
Ferdinando Ivano AmbraDepartment of Motor Science and Wellness, University of Naples "Parthenope", Naples, Italy.
Maria SanninoNeurological Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy.
Filomena GaleoneFrailty Unit, ASL Napoli 1 Centro, Naples, Italy.
Sabrina EspositoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Bruno RongaNeurological Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy.
Ciro Rosario IlardiNeurological Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe present normative study aimed to (1) develop the Italian version of the Starkstein Apathy Scale (SAS-I) and (2) construct a shortened version including only the most sensitive items to "pure apathy" experiences.

methodsThe normative sample included 392 healthy subjects. A regression-based procedure was used to explore the effects of sex, age, and education on the raw SAS-I score. A correction grid was designed for adjusting raw scores by adding or subtracting the contribution of any significant variable and net of sociodemographic interindividual differences. Cutoff scores were also calculated and fixed at the external tolerance limit on the ninety-fifth centile. To obtain the shortened version, each SAS-I item was correlated with the Beck's Depression Inventory (BDI) score. The only items showing no correlation with BDI were implemented to bypass the well-known overlap between apathetic and depressive symptoms.

resultsThe mean raw SAS-I score was 11.27 (SD = 4.42). A significant education effect was observed, with highly educated subjects obtaining lower scores than lowly educated ones. The proposed general cutoff score was 20.68. The SAS-I had fair internal consistency and discriminant validity. Internal consistency increased by removing item 3. The new SAS-6 included items 1, 2, 4, 10, 11, and 13 of the original scale.

conclusionThe SAS-I is a reliable assessment tool to support the diagnosis of apathy. The SAS-6, instead, is a brief questionnaire useful for quickly screening apathetic symptoms in outpatient practice, addressing or not the clinician to further investigations.

Indexed as

ApathyEducational StatusHumansItalyOutpatientsPsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsSurveys and QuestionnairesApathyAssessmentItalyNormative studyStarkstein Apathy Scale

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.