ArticleThe international journal of cardiovascular imaging2021
Left atrial strain imaging differentiates cardiac amyloidosis and hypertensive heart disease.
Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Usefulness of Strain Echocardiography in Heart Failure with Preserved Ejection Fraction.Journal of clinical medicine · 2026Review
- Atrial Fibrillation in Infiltrative Cardiomyopathies: From Atrial Cardiomyopathy Imaging to Targeted Management-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Clinical and prognostic impact of left atrial strain in non-ischemic cardiomyopathies.The international journal of cardiovascular imaging · 2026Review
- Triplane Left Atrial Reservoir Strain in Cardiac Amyloidosis: A Comparative Study with Rhythm-Matched Controls.Clinics and practice · 2026Article
- Multimodality Imaging in Cardiac Amyloidosis.Journal of clinical medicine · 2025Review
- Subclinical Cardiac Involvement in Asymptomatic ATTR Mutation Carriers: Insights from Cardiac MRI, Myocardial Strain, and Mapping Techniques.Journal of cardiovascular development and disease · 2025Article
- A Tale of Two Diseases: Decoding Aortic Stenosis and Cardiac Amyloidosis.Journal of clinical medicine · 2025Review
- Atrial cardiomyopathy in cardiac amyloidosis: clinical imaging and manifestations.NPJ cardiovascular health · 2025Article
- Multi-modality artificial intelligence-based transthyretin amyloid cardiomyopathy detection in patients with severe aortic stenosis.European journal of nuclear medicine and molecular imaging · 2025Article
- Diagnostic and prognostic value of the left atrial myopathy evaluation in cardiac amyloidosis using echocardiography.ESC heart failure · 2024Article
- Cardiac amyloidosis is not a single disease: a multiparametric comparison between the light chain and transthyretin forms.ESC heart failure · 2024Article
- Distinctive Deposition Patterns of Sporadic Transthyretin-Derived Amyloidosis in the Atria: A Forensic Autopsy-Based Study.International journal of molecular sciences · 2024Article
- Assessing left atrial dysfunction in cardiac amyloidosis using LA-LV strain slope.European heart journal. Imaging methods and practice · 2024Article
- Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.Heart failure reviews · 2024Review
- The Clinical Applications of Left Atrial Strain: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Relative apical sparing obtained with speckle tracking echocardiography is not a sensitive parameter for diagnosing light-chain cardiac amyloidosis.Quantitative imaging in medicine and surgery · 2024Article
- Current Perspectives on Atrial Amyloidosis: A Narrative Review.Reviews in cardiovascular medicine · 2024Review
- Right heart and left atrial strain to differentiate cardiac amyloidosis and Fabry disease.Scientific reports · 2024Article
- Cardiac amyloidosis and aortic stenosis: a state-of-the-art review.European heart journal open · 2023Review
- The correlation of left atrial dysfunction and amyloid load in patients with immunoglobulin light-chain cardiac amyloidosis: a 3T cardiac magnetic resonance study.The British journal of radiology · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Echocardiographic diagnosis of cardiac amyloidosis (CA) can be difficult to differentiate from increased left ventricular (LV) wall thickness from hypertensive heart disease. The aim of this study was to evaluate left atrial (LA) function and deformation using strain and strain rate (SR) imaging in cardiac amyloidosis. We reviewed 44 cases of CA confirmed by tissue biopsy or a combination of clinical and cardiac imaging data. Cases were classified according two subgroups: amyloid light chain (AL) or amyloid transthyretin (ATTR). These subjects underwent 2D-Speckle tracking echocardiographic derived (STE) LA strain analysis. These were compared to 25 hypertensive (HT) patients with increased LV wall thickness. The three phases of LA function were evaluated using strain and strain rate parameters. Despite a similar increase in LV wall thickness, all LA strain parameters were significantly reduced in the AL cohort compared to the HT cohort (reservoir strain/LAs: 11.0 vs. 24.8%, p < 0.05). The ATTR cohort had significantly thicker LV walls and higher atrial fibrillation burden compared to AL and HT patients but similar reduction in LA strain values compared to AL group. A reservoir strain (S-LAs) cut off value of 20% was 86.4% sensitive and 88.6% specific for detecting CA compared to HT heart disease in this cohort. LA strain parameters were able to identify LA dysfunction in all types of CA. LA function in CA is significantly worse compared with hypertensive patients despite similar increase in LV wall thickness. In combination with other clinical and imaging features, LA strain may provide incremental value in differentiating cardiac amyloidosis from increased wall thickness secondary to hypertension.
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