Evidence map›Paper›PMID 32728983›Full record

ArticleJournal of digital imaging2020

Binary Classification of Alzheimer's Disease Using sMRI Imaging Modality and Deep Learning.

Ahsan Bin Tufail, Yong-Kui Ma, Qiu-Na Zhang

Abstract read
In one paragraph

Article in Journal of digital imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Article
  4. A vision-language foundation model for Alzheimer's disease diagnosis using MRI and clinical data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ahsan Bin TufailHarbin Institute of Technology, Harbin, China.
Yong-Kui MaHarbin Institute of Technology, Harbin, China. yk_ma@hit.edu.cn.
Qiu-Na ZhangHarbin Institute of Technology, Harbin, China.

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276
6 · The paper itself

Abstract

Alzheimer's disease (AD) is an irreversible devastative neurodegenerative disorder associated with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for the development of possible future treatment option(s). Structural magnetic resonance images (sMRI) play an important role to help in understanding the anatomical changes related to AD especially in its early stages. Conventional methods require the expertise of domain experts and extract hand-picked features such as gray matter substructures and train a classifier to distinguish AD subjects from healthy subjects. Different from these methods, this paper proposes to construct multiple deep 2D convolutional neural networks (2D-CNNs) to learn the various features from local brain images which are combined to make the final classification for AD diagnosis. The whole brain image was passed through two transfer learning architectures; Inception version 3 and Xception, as well as a custom Convolutional Neural Network (CNN) built with the help of separable convolutional layers which can automatically learn the generic features from imaging data for classification. Our study is conducted using cross-sectional T1-weighted structural MRI brain images from Open Access Series of Imaging Studies (OASIS) database to maintain the size and contrast over different MRI scans. Experimental results show that the transfer learning approaches exceed the performance of non-transfer learning-based approaches demonstrating the effectiveness of these approaches for the binary AD classification task.

Indexed as

Alzheimer DiseaseDeep LearningCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingArtificial neural networksClassificationDeep learningMedical imagingMRITransfer learning

Identifiers

PMID32728983
PMCPMC7573078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.