Evidence map›Paper›PMID 32728907›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2020

Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities.

Edinilton Muniz Carvalho, Tercio de Freitas Paulo, Alix Sournia Saquet, Bruno Lopes Abbadi, Fernanda Souza Macchi, Cristiano Valim Bizarro, Rafael de Morais Campos, Talles Luann Abrantes Ferreira, Nilberto Robson Falcão do Nascimento, Luiz Gonzaga França Lopes and 3 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Structure-Reactivity Relationships inInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Edinilton Muniz CarvalhoCNRS, Laboratoire de Chimie de Coordination, LCC, UPR 8241, 205 Route de Narbonne, BP 44099, 31077, Cedex 4 Toulouse, France.
Tercio de Freitas PauloCNRS, Laboratoire de Chimie de Coordination, LCC, UPR 8241, 205 Route de Narbonne, BP 44099, 31077, Cedex 4 Toulouse, France.
Alix Sournia SaquetCNRS, Laboratoire de Chimie de Coordination, LCC, UPR 8241, 205 Route de Narbonne, BP 44099, 31077, Cedex 4 Toulouse, France.
Bruno Lopes AbbadiCentro de Pesquisas Em Biologia Molecular E Funcional (CPBMF), Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil.
Fernanda Souza MacchiCentro de Pesquisas Em Biologia Molecular E Funcional (CPBMF), Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil.
Cristiano Valim BizarroCentro de Pesquisas Em Biologia Molecular E Funcional (CPBMF), Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil.
Rafael de Morais CamposLaboratório de Farmacologia Cardiovascular E Renal, Universidade Estadual Do Ceará, Campus do Itaperi, Fortaleza, CEP, 60714-903, Brazil.
Talles Luann Abrantes FerreiraLaboratório de Farmacologia Cardiovascular E Renal, Universidade Estadual Do Ceará, Campus do Itaperi, Fortaleza, CEP, 60714-903, Brazil.
Nilberto Robson Falcão do NascimentoLaboratório de Farmacologia Cardiovascular E Renal, Universidade Estadual Do Ceará, Campus do Itaperi, Fortaleza, CEP, 60714-903, Brazil.
Luiz Gonzaga França LopesGrupo de Bioinorgânica, Departamento de Química Orgânica E Inorgânica, Universidade Federal Do Ceará, Campus Pici, Fortaleza, CE, 60455-760, Brazil.
Remi ChauvinCNRS, Laboratoire de Chimie de Coordination, LCC, UPR 8241, 205 Route de Narbonne, BP 44099, 31077, Cedex 4 Toulouse, France.
Eduardo Henrique Silva SousaGrupo de Bioinorgânica, Departamento de Química Orgânica E Inorgânica, Universidade Federal Do Ceará, Campus Pici, Fortaleza, CE, 60455-760, Brazil. eduardohss@dqoi.ufc.br.
Vania Bernardes-GénissonCNRS, Laboratoire de Chimie de Coordination, LCC, UPR 8241, 205 Route de Narbonne, BP 44099, 31077, Cedex 4 Toulouse, France. vania.bernardes-genisson@lcc-toulouse.fr.
Pontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Estadual do Ceará · BRLaboratoire de Chimie de Coordination · FRUniversidade Federal do Ceará · BRUniversité Fédérale de Toulouse Midi-Pyrénées · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release active species upon enzymatic oxidative activation, is devised. This is exemplified by combining two anti-mycobacterial drugs: pyrazinamide (first line) and delamanid (third line) whose active metabolites are pyrazinoic acid (PyzCOOH) and likely nitroxyl (HNO (or NO

Indexed as

AmidohydrolasesAntitubercular AgentsCoordination ComplexesDrug DiscoveryElectron Spin Resonance SpectroscopyFerrous CompoundsHydrogen PeroxideHydroxamic AcidsIronLigandsMycobacterium tuberculosisNitrogen OxidesOxidation-ReductionPyrazinamideVasodilationAmidohydrolasesAntitubercular AgentsCoordination ComplexesFerrous CompoundsHydrogen PeroxideHydroxamic AcidsIronLigandsNitrogen Oxidesnitroxylpentacyanoferrate (II)Pyrazinamidepyrazinamide deamidasepyrazinoic acidBlood vessel vasodilationHybrid pro-drug activationMetallodrugPyrazinamideSodium nitroprusside derivativeTuberculosis

Identifiers

PMID32728907
OpenAlexW3046121038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.