ArticleDiabetologia2020
The metabolic syndrome in pregnancy and its association with child telomere length.
Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Telomere Length in Metabolic Syndrome: Mechanisms, Epidemiology and Clinical Implications: A Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization.Nature communications · 2025Article
- Telomere length across the spectrum of metabolic health: an analysis from the LIPIDOGEN2015 study.Archives of medical science : AMS · 2025Article
- General Practitioners perspectives on infant telomere length screening after a pregnancy complication: a qualitative analysis.Family practice · 2024Article
- Prevalence and associated factors of metabolic syndrome among pregnant Ethiopian women: a hospital-based cross-sectional study.Scientific reports · 2024Article
- Association of gestational cardiovascular health with infant neurodevelopment: A prospective study in Hefei of Anhui, China.Preventive medicine reports · 2024Article
- The consumption ofRedox report : communications in free radical research · 2023Article
- Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length.Nutrients · 2023Review
- Maternal and Neonatal Outcomes in Women with Metabolic Syndrome and Substance Use Disorder.Life (Basel, Switzerland) · 2023Article
- Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka.BMC pregnancy and childbirth · 2023Article
- Maternal metabolic syndrome in pregnancy and child development at age 5: exploring mediating mechanisms using cord blood markers.BMC medicine · 2023Article
- Early pregnancy cardio metabolic risk factors and the prevalence of metabolic syndrome 10 years after the first pregnancy.PloS one · 2023Article
- Longitudinal Association of Telomere Dynamics with Obesity and Metabolic Disorders in Young Children.Nutrients · 2022Article
- Vitamin D Levels During Pregnancy Are Associated With Offspring Telomere Length: A Longitudinal Mother-Child Study.The Journal of clinical endocrinology and metabolism · 2022Observational
- Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.Diabetologia · 2021Article
- Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging.Biology · 2021Review
- Understanding the Link Between Maternal Overnutrition, Cardio-Metabolic Dysfunction and Cognitive Aging.Frontiers in neuroscience · 2021Review
- Article
- Telomere Dysfunction in Oocytes and Embryos From Obese Mice.Frontiers in cell and developmental biology · 2021Article
- Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker.Life sciences · 2020Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
aims/hypothesisThe aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age.
methodsThe Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international prospective cohort of nulliparous pregnant women recruited from Australia, New Zealand, Ireland and the UK (N = 5628). The current analysis is a 10 year follow-up of SCOPE pregnant women and their children, from the Australian cohort. Clinical data collected at 14-16 weeks' gestation during the SCOPE study were used to diagnose the metabolic syndrome using IDF criteria. Telomere length, a biomarker of ageing, was assessed by quantitative PCR from children's saliva collected at 10 years of age.
resultsIn women who completed follow-up (n = 255), 20% had the metabolic syndrome in pregnancy. After adjusting for a range of confounders, children of mothers who had the metabolic syndrome in pregnancy had 14% shorter telomeres than children of mothers without the metabolic syndrome in pregnancy (mean difference -0.36 [95% CI -0.74, 0.01]). Height- and weight-for-age, and BMI z scores were similar in children of mothers who did and did not have the metabolic syndrome during pregnancy. CONCLUSIONS/
interpretationChildren of mothers who had the metabolic syndrome in pregnancy have shorter telomeres, a biomarker of accelerated ageing. These findings warrant further studies in larger cohorts of children, as well as investigations into whether telomere length measured in cord blood associates with telomere length in childhood.
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