Evidence map›Paper›PMID 32728881›Full record

Trial reportEuropean journal of nutrition2021

Dietary macronutrients do not differently affect postprandial vascular endothelial function in apparently healthy overweight and slightly obese men.

Ellen T H C Smeets, Ronald P Mensink, Peter J Joris

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03139890 (The Effects of Macronutrients on Postprandial Vascular Function in Overweight and Slightly Obese Men), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03139890 nacompletednot on this map

The Effects of Macronutrients on Postprandial Vascular Function in Overweight and Slightly Obese Men

TypeinterventionalSponsorMaastricht University Medical CenterRan2017 to 2018Enrolled20ConditionsDietary Fats, Carbohydrates, Proteins, MacronutrientsArmsHigh-fat (HF-LC-LP) milkshake, High-carbohydrate (LF-HC-LP) milkshake, High-protein (LF-LC-HP) milkshake
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ellen T H C SmeetsDepartment of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Ronald P MensinkDepartment of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Peter J JorisDepartment of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD, Maastricht, The Netherlands. p.joris@maastrichtuniversity.nl.
Maastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWell-designed trials comparing side-by-side effects of macronutrients on postprandial endothelial function are missing. Therefore, we investigated under well-controlled and isocaloric condition effects of fat, carbohydrates, and protein on postprandial endothelial function as assessed by brachial artery flow-mediated vasodilation (FMD), an important non-invasive technique to assess endothelial function.

methodsEighteen apparently healthy overweight and slightly obese men (BMI 26.0-35.0 kg/m

resultsA postprandial decrease of 1.2% point in FMD was observed after the high-protein meal (P = 0.015). However, postprandial changes did not differ between meals (P = 0.45). An increase in baseline brachial artery diameters was observed after the high-protein meal (P < 0.001) and changes differed between meals (P = 0.020). A meal*time interaction was found for plasma glucose concentrations, with the most pronounced increases after the high-carbohydrate meal at T15, T30, T60, and T90 (P < 0.05). A significant time and meal (P < 0.001), but no time*meal effect (P = 0.06) was found for serum insulin concentrations. Increases in serum triacylglycerol concentrations did not differ between meals (P = 0.014).

conclusionMacronutrients did not differently affect postprandial endothelial function in apparently healthy overweight and slightly obese men.

trial registrationTrial registration number (ClinicalTrials.gov) NCT03139890 in May 2017.

Indexed as

OverweightPostprandial PeriodBlood GlucoseCross-Over StudiesDietary FatsDouble-Blind MethodEndothelium, VascularHumansInsulinMaleNutrientsObesityTriglyceridesBlood GlucoseDietary FatsInsulinNutrientsTriglyceridesDietary macronutrientsEndothelial functionFlow-mediated vasodilationNitric oxidePostprandial

Identifiers

PMID32728881
PMCPMC7987601
OpenAlexW3045713788

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.