Evidence map›Paper›PMID 32728879›Full record

Trial reportEuropean journal of nutrition2021

Effect of coffee and cocoa-based confectionery containing coffee on markers of cardiometabolic health: results from the pocket-4-life project.

Daniela Martini, Alice Rosi, Michele Tassotti, Monica Antonini, Margherita Dall'Asta, Letizia Bresciani, Federica Fantuzzi, Valentina Spigoni, Raúl Domínguez-Perles, Donato Angelino and 10 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03166540 (Bioavailability and Beneficial Properties of Espresso Coffee and Confectionery Derived Coffee Bioactive Compounds), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03166540 nacompletednot on this map

Bioavailability and Beneficial Properties of Espresso Coffee and Confectionery Derived Coffee Bioactive Compounds

TypeinterventionalSponsorUniversity of ParmaRan2017 to 2017Enrolled21ConditionsDiet Modification, Cardiovascular Risk Factor, Nutritional and Metabolic DiseasesArmscup of espresso coffee, cocoa-based products containing coffee
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 3 countries.

Daniela MartiniHuman Nutrition Unit, Department of Veterinary Sciences, University of Parma, University Hospital Building 27, Via Gramsci 14, 43126, Parma, Italy.ORCID http://orcid.org/0000-0001-8298-926X
Alice RosiHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125, Parma, Italy.ORCID http://orcid.org/0000-0001-8533-797X
Michele TassottiHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125, Parma, Italy.
Monica AntoniniDepartment of Medicine and Surgery, University of Parma, 43126, Parma, Italy.
Margherita Dall'AstaHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125, Parma, Italy.ORCID http://orcid.org/0000-0002-0558-0337
Letizia BrescianiHuman Nutrition Unit, Department of Veterinary Sciences, University of Parma, University Hospital Building 27, Via Gramsci 14, 43126, Parma, Italy.ORCID http://orcid.org/0000-0002-7768-4987
Federica FantuzziDepartment of Medicine and Surgery, University of Parma, 43126, Parma, Italy.
Valentina SpigoniDepartment of Medicine and Surgery, University of Parma, 43126, Parma, Italy.ORCID http://orcid.org/0000-0001-5716-1671
Raúl Domínguez-PerlesResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, University Campus of Espinardo, Edif. 25, 30100, Murcia, Spain.ORCID http://orcid.org/0000-0001-6232-712X
Donato AngelinoHuman Nutrition Unit, Department of Veterinary Sciences, University of Parma, University Hospital Building 27, Via Gramsci 14, 43126, Parma, Italy.ORCID http://orcid.org/0000-0002-5436-7428
Cristian RicciPediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4113-8682
Soledad Del Pozo-LuengoClinical Analysis Service, University Hospital Virgen de la Arrixaca, 30120, El Palmar, Murcia, Spain.
Pedro Luis TornelClinical Analysis Service, University Hospital Virgen de la Arrixaca, 30120, El Palmar, Murcia, Spain.
Francesca ScazzinaHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125, Parma, Italy.ORCID http://orcid.org/0000-0002-5372-8658
Angel Gil-IzquierdoResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, University Campus of Espinardo, Edif. 25, 30100, Murcia, Spain.ORCID http://orcid.org/0000-0001-7646-0386
Alessandra Dei CasDepartment of Medicine and Surgery, University of Parma, 43126, Parma, Italy.ORCID http://orcid.org/0000-0002-8666-4849
Furio BrighentiHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125, Parma, Italy.ORCID http://orcid.org/0000-0001-8441-4611
Riccardo BonadonnaDepartment of Medicine and Surgery, University of Parma, 43126, Parma, Italy.
Daniele Del RioHuman Nutrition Unit, Department of Veterinary Sciences, University of Parma, University Hospital Building 27, Via Gramsci 14, 43126, Parma, Italy. daniele.delrio@unipr.it.ORCID http://orcid.org/0000-0001-5394-1259
Pedro MenaHuman Nutrition Unit, Department of Food and Drugs, University of Parma, 43125, Parma, Italy.ORCID http://orcid.org/0000-0003-2150-2977
University of Parma · ITCentro de Edafología y Biología Aplicada del Segura · ESHospital Universitario Virgen de la Arrixaca · ESLeipzig University · DEUniversità Cattolica del Sacro Cuore · ITUniversity of Teramo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCoffee is an important source of bioactive compounds, including caffeine, trigonelline, and phenolic compounds. Several studies have highlighted the preventive effects of coffee consumption on major cardiometabolic (CM) diseases, but the impact of different coffee dosages on markers of CM risk in a real-life setting has not been fully understood. This study aimed to investigate the effect of coffee and cocoa-based confectionery containing coffee consumption on several CM risk factors in healthy subjects.

methodsIn a three-arm, crossover, randomized trial, 21 volunteers were assigned to consume in a random order for 1 month: 1 cup of espresso coffee/day, 3 cups of espresso coffee/day, and 1 cup of espresso coffee plus 2 cocoa-based products containing coffee, twice per day. At the last day of each treatment, blood samples were collected and used for the analysis of inflammatory markers, trimethylamine N-oxide, nitric oxide, blood lipids, and markers of glucose/insulin metabolism. Moreover, anthropometric parameters and blood pressure were measured. Finally, food consumption during the interventions was monitored.

resultsAfter 1 month, energy intake did not change among treatments, while significant differences were observed in the intake of saturated fatty acids, sugars, and total carbohydrates. No significant effect on CM markers was observed following neither the consumption of different coffee dosages nor after cocoa-based products containing coffee.

conclusionsThe daily consumption of common dosages of coffee and its substitution with cocoa-based products containing coffee showed no effect on CM risk factors in healthy subjects. TRIAL REGISTRATION NUMBER: Registered at clinicaltrials.gov as NCT03166540, May 21, 2017.

Indexed as

CacaoCardiovascular DiseasesChocolateCandyCoffeeCross-Over StudiesHumansCoffeeCardiometabolic healthCoffeeDietary patternRandomized-controlled trialReal-life setting

Identifiers

PMID32728879
PMCPMC7987697
OpenAlexW3045678157

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.