Evidence map›Paper›PMID 32728654›Full record

ReviewJournal of the Endocrine Society2020

The Impact of SARS-Cov-2 Virus Infection on the Endocrine System.

Noel Pratheepan Somasundaram, Ishara Ranathunga, Vithiya Ratnasamy, Piyumi Sachindra Alwis Wijewickrama, Harsha Anuruddhika Dissanayake, Nilukshana Yogendranathan, Kavinga Kalhari Kobawaka Gamage, Nipun Lakshitha de Silva, Manilka Sumanatilleke, Prasad Katulanda and 1 more

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Journal of the Endocrine Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04662437 completednot on this map

The Status of Parathyroid Hormone Secretion and Its Relationship With White Blood Cells, Neutrophil / Lymphocyte Ratio, c Reactive Protein, Fibrinogen, Procalcitonin, Ferritin and D-dimer in Hospitalized Covid-19 Patients

TypeobservationalSponsorBezmialem Vakif UniversityRan2020 to 2020Enrolled150ConditionsCOVID-19 Infection, Parathyroid Gland, Parathyroid Hormone, CalciumArmsVenous blood was collected for biochemistry testing
NCT05185700 unknown statusnot on this mapstarted 2022, after this paper: background citation

Post Covid 19 Syndrome

TypeobservationalSponsorAssiut UniversityRan2022 to 2023Enrolled180ConditionsCOVID-19Armspost covid 19 symtoms
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
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  5. Review
  6. The prognostic significance of insulin resistance in COVID-19: a review.Journal of diabetes and metabolic disorders · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. COVID-19 infection and thyroid function.Endocrine and metabolic science · 2022
    Article
  17. Article
  18. Review
  19. Adrenal crisis in a patient with APS2 due to COVID-19: A case report.Journal of family medicine and primary care · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Noel Pratheepan SomasundaramDiabetes and Endocrine Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.ORCID 0000-0002-6241-7501
Ishara RanathungaDiabetes and Endocrine Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.ORCID 0000-0002-2188-5309
Vithiya RatnasamyUniversity Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Piyumi Sachindra Alwis WijewickramaDiabetes and Endocrine Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Harsha Anuruddhika DissanayakeUniversity Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Nilukshana YogendranathanUniversity Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Kavinga Kalhari Kobawaka GamageDiabetes and Endocrine Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Nipun Lakshitha de SilvaDiabetes and Endocrine Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Manilka SumanatillekeDiabetes and Endocrine Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Prasad KatulandaUniversity Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Ashley Barry GrossmanOxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, London, UK.
National Hospital of Sri Lanka · LKGeneral Sir John Kotelawala Defence University · LKQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has spread across the globe rapidly causing an unprecedented pandemic. Because of the novelty of the disease, the possible impact on the endocrine system is not clear. To compile a mini-review describing possible endocrine consequences of SARS-CoV-2 infection, we performed a literature survey using the key words Covid-19, Coronavirus, SARS CoV-1, SARS Cov-2, Endocrine, and related terms in medical databases including PubMed, Google Scholar, and MedARXiv from the year 2000. Additional references were identified through manual screening of bibliographies and via citations in the selected articles. The literature review is current until April 28, 2020. In light of the literature, we discuss SARS-CoV-2 and explore the endocrine consequences based on the experience with structurally-similar SARS-CoV-1. Studies from the SARS -CoV-1 epidemic have reported variable changes in the endocrine organs. SARS-CoV-2 attaches to the ACE2 system in the pancreas causing perturbation of insulin production resulting in hyperglycemic emergencies. In patients with preexisting endocrine disorders who develop COVID-19, several factors warrant management decisions. Hydrocortisone dose adjustments are required in patients with adrenal insufficiency. Identification and management of critical illness-related corticosteroid insufficiency is crucial. Patients with Cushing syndrome may have poorer outcomes because of the associated immunodeficiency and coagulopathy. Vitamin D deficiency appears to be associated with increased susceptibility or severity to SARS-CoV-2 infection, and replacement may improve outcomes. Robust strategies required for the optimal management of endocrinopathies in COVID-19 are discussed extensively in this mini-review.

Indexed as

COVID-19EndocrineSARS-CoV2

Identifiers

PMID32728654
PMCPMC7337839
OpenAlexW3040323020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.