Evidence map›Paper›PMID 32728481›Full record

ArticleNPJ vaccines2020

Humoral immune response to tick-borne encephalitis vaccination in allogeneic blood and marrow graft recipients.

Nicole Harrison, Katharina Grabmeier-Pfistershammer, Alexandra Graf, Ilse Schwarzinger, Judith H Aberle, Karin Stiasny, Hildegard Greinix, Werner Rabitsch, Peter Kalhs, Michael Ramharter and 2 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01991067 (Characterization of Humoral and Cellular Immunity for Tick-borne Encephalitis), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01991067 phase2completednot on this map

Characterization of Humoral and Cellular Immunity for Tick-borne Encephalitis (TBE) Vaccination in Allogeneic Blood and Marrow Graft Recipients: a Pilot Study

TypeinterventionalSponsorMedical University of ViennaRan2014 to 2018Enrolled34ConditionsTick Borne EncephalitisArmsTBE virus vaccine
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Tick-Borne Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023
    Article
  3. Article
  4. Infectious complications and vaccines.Hematology. American Society of Hematology. Education Program · 2021
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Nicole HarrisonDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Katharina Grabmeier-PfistershammerDivision of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Alexandra GrafSection of Medical Statistics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
Ilse SchwarzingerDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Judith H AberleCenter for Virology, Medical University of Vienna, Vienna, Austria.
Karin StiasnyCenter for Virology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1902-8674
Hildegard GreinixDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Werner RabitschBone Marrow Transplantation Unit, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Peter KalhsBone Marrow Transplantation Unit, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Michael RamharterDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Heinz BurgmannDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Christina ForstnerDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-4427-2839
Medical University of Vienna · ATJena University Hospital · DEMedical University of Graz · ATStatistics Austria · ATUniversität Hamburg · DE

Funding

Austrian Science Fund FWF KLI 372
6 · The paper itself

Abstract

The aim of this prospective study was to characterize the humoral immune response to TBE vaccination after hematopoietic stem cell transplantation (HSCT). Nineteen adult patients 11-13 months after HSCT and 15 age-matched immunocompetent adults received up to three TBE vaccinations. Antibodies against TBE virus were measured by neutralization test (NT). As primary endpoint, the antibody response (NT titer of ≥10 and at least a twofold increase from baseline 4 weeks after second vaccination) was compared between patients and controls using Fisher exact test. Prior vaccination, 15 (79%) HSCT patients still had detectable neutralizing antibodies. At primary endpoint, the antibody response was significantly lower in patients than in controls (35% versus 93%;

Indexed as

Haematological cancerInactivated vaccinesViral infection

Identifiers

PMID32728481
PMCPMC7381595
OpenAlexW3044610857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.