ArticleBone & joint research2020
Anti-fibrotic effects of the antihistamine ketotifen in a rabbit model of arthrofibrosis.
Article in Bone & joint research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Immunomodulatory and Anti-Inflammatory Effects of Ketotifen Versus Vitamin E in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Pilot Study.Drug design, development and therapy · 2026Trial
- Arthrofibrosis After Total Knee Arthroplasty: Biological Mechanisms, Diagnosis, and Treatment: An International Consensus Symposium.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2026Article
- Design and validation of a biomechanics device for preclinical arthrofibrosis models.Bone & joint research · 2026Article
- Development of a novel external fixation device for inducing knee arthrofibrosis in rats.Scientific reports · 2026Article
- New Clues to the Challenge of Knee Arthrofibrosis: From Molecules to Therapies.The Journal of the American Academy of Orthopaedic Surgeons · 2026Review
- Prospective clinical trial analyzing serum mast cell tryptase levels and arthrofibrosis rates after total knee arthroplasty.Bone & joint research · 2025Article
- An Abbreviated Rabbit Knee Model of Joint Contracture.Tissue engineering. Part C, Methods · 2025Article
- Efficacy of ADIPOR1 and ADIPOR2 peptide-agonist AdipoRon in preventing contracture in a rabbit model of arthrofibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Ketotifen directly modifies the fibrotic response of human skin fibroblasts.Scientific reports · 2024Article
- Nonsteroidal Anti-Inflammatory Drugs and Oral Corticosteroids Mitigated the Risk of Arthrofibrosis After Total Knee Arthroplasty.The Journal of arthroplasty · 2023Article
- Management of the stiff elbow: a literature review.EFORT open reviews · 2023Review
- Metformin improves fibroblast metabolism and ameliorates arthrofibrosis in rats.Journal of orthopaedic translation · 2023Article
- The Safety of Adiponectin Receptor Agonist AdipoRon in a Rabbit Model of Arthrofibrosis.Tissue engineering. Part C, Methods · 2023Article
- Biochemical markers of postsurgical knee arthrofibrosis: A systematic review.Journal of orthopaedics · 2023Review
- Knee immobilization reproduces key arthrofibrotic phenotypes in mice.Bone & joint research · 2023Article
- Immune cell populations differ in patients undergoing revision total knee arthroplasty for arthrofibrosis.Scientific reports · 2022Article
- Developmental endothelial locus-1 attenuates palmitate-induced apoptosis in tenocytes through the AMPK/autophagy-mediated suppression of inflammation and endoplasmic reticulum stress.Bone & joint research · 2022Article
- Human outgrowth knee fibroblasts from patients undergoing total knee arthroplasty exhibit a unique gene expression profile and undergo myofibroblastogenesis upon TGFβ1 stimulation.Journal of cellular biochemistry · 2022Article
- Intra-articular celecoxib improves knee extension regardless of surgical release in a rabbit model of arthrofibrosis.Bone & joint research · 2022Article
- Arthroscopic management of elbow stiffness.Journal of experimental orthopaedics · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsArthrofibrosis is a relatively common complication after joint injuries and surgery, particularly in the knee. The present study used a previously described and validated rabbit model to assess the biomechanical, histopathological, and molecular effects of the mast cell stabilizer ketotifen on surgically induced knee joint contractures in female rabbits.
methodsA group of 12 skeletally mature rabbits were randomly divided into two groups. One group received subcutaneous (SQ) saline, and a second group received SQ ketotifen injections. Biomechanical data were collected at eight, ten, 16, and 24 weeks. At the time of necropsy, posterior capsule tissue was collected for histopathological and gene expression analyses (messenger RNA (mRNA) and protein).
resultsAt the 24-week timepoint, there was a statistically significant increase in passive extension among rabbits treated with ketotifen compared to those treated with saline (p = 0.03). However, no difference in capsular stiffness was detected. Histopathological data failed to demonstrate a decrease in the density of fibrous tissue or a decrease in α-smooth muscle actin (α-SMA) staining with ketotifen treatment. In contrast, tryptase and α-SMA protein expression in the ketotifen group were decreased when compared to saline controls (p = 0.007 and p = 0.01, respectively). Furthermore, there was a significant decrease in α-SMA (
conclusionCollectively, these data suggest that ketotifen mitigates the severity of contracture formation in a rabbit model of arthrofibrosis.
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