ArticleTherapeutic advances in psychopharmacology2020
The effect of COVID-19 on absolute neutrophil counts in patients taking clozapine.
Article in Therapeutic advances in psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Clozapine Therapy and COVID-19: A Systematic Review of the Prevalence Rates, Health Outcomes, Hematological Markers, and Patient Perspectives.Schizophrenia bulletin · 2023Pooled it
- COVID-19 disease outcomes in patients receiving clozapine versus other antipsychotics: a national study in Qatar.Frontiers in psychiatry · 2025Article
- A case report on the effects of COVID-19 on ANC monitoring in a patient on long-term clozapine treatment.The mental health clinician · 2023Article
- Clozapine treatment and risk of severe COVID-19 infection.Acta psychiatrica Scandinavica · 2022Article
- Clozapine and Neutropenia in Patients with Schizophrenia and SARS-CoV-2 Infection.Neuropsychiatric disease and treatment · 2022Article
- Neutropenia after the coadministration of clozapine and nirmatrelvir-ritonavir in a patient with SARS-CoV-2 infection: A case report with a literature review.Frontiers in psychiatry · 2022Article
- Psychotropics and COVID-19: An analysis of safety and prophylaxis.L'Encephale · 2021Article
- Self-limiting severe neutropenia in a patient with COVID-19.BMJ case reports · 2021Article
- Reduction in Absolute Neutrophil Counts in Patient on Clozapine Infected with COVID-19.International journal of environmental research and public health · 2021Review
- COVID-19 infection causes a reduction in neutrophil counts in patients taking clozapine.Journal of psychiatry & neuroscience : JPN · 2021Article
- Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety-Particularities in the Context of COVID-19.Brain sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clozapine is associated with haematological side effects, including neutropaenia, which can signal impending life-threatening agranulocytosis. Patients with COVID-19 infection frequently experience lymphopaenia, but not neutropaenia. We present 13 patients established on clozapine who developed COVID-19 infection. There were no significant differences in total white cell or neutrophil counts between pre-COVID-19, intra-COVID-19 or post-COVID-19 periods. We therefore suggest that patients who develop COVID-19 should generally have their clozapine treatment continued. Patients taking clozapine who develop neutroapaenia during COVID-19 infection should be investigated and monitored as in normal practice, because changes in neutrophil counts cannot be assumed to be due to the viral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.