Evidence map›Paper›PMID 32728250›Full record

ArticleNature2020

Global reference mapping of human transcription factor footprints.

Jeff Vierstra, John Lazar, Richard Sandstrom, Jessica Halow, Kristen Lee, Daniel Bates, Morgan Diegel, Douglas Dunn, Fidencio Neri, Eric Haugen and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers.

0numbers the graph read from it
0cells of the map it votes in
261citing papers in PubMed
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

261 citing papers in PubMed, 438 citations in OpenAlex.

  1. Article
  2. AlphaGenome Atlas:medRxiv : the preprint server for health sciences · 2026
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  14. Article
  15. EpiATLAS - a reference for human epigenomic research.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

201 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Jeff VierstraAltius Institute for Biomedical Sciences, Seattle, WA, USA. jvierstra@altius.org.ORCID http://orcid.org/0000-0001-6406-8563
John LazarAltius Institute for Biomedical Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3142-1858
Richard SandstromAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Jessica HalowAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Kristen LeeAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Daniel BatesAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Morgan DiegelAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Douglas DunnAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Fidencio NeriAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Eric HaugenAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Eric RynesAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Alex ReynoldsAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Jemma NelsonAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Audra JohnsonAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Mark FrerkerAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Michael BuckleyAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Rajinder KaulAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Wouter MeulemanAltius Institute for Biomedical Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1196-5401
John A StamatoyannopoulosAltius Institute for Biomedical Sciences, Seattle, WA, USA. jstam@altius.org.ORCID http://orcid.org/0000-0002-2664-5769
Altius Institute for Biomedical Sciences · USUniversity of Washington · US

Funding

ENCODE Mapping Center-A Comprehensive Catalog of DNase I Hypersensitive SitesUM1HG009444 · NHGRI · ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES · PI STAMATOYANNOPOULOS, JOHN A · 2017 to 2021
$15.9M
A Comprehensive Catalog of Dnasel Hypersensitive SitesU54HG007010 · NHGRI · UNIVERSITY OF WASHINGTON · PI STAMATOYANNOPOULOS, JOHN A · 2012 to 2016
$12.4M
Elucidation of the organizing principles of the regulatory genome through large-scale data integrationR35HG011317 · NHGRI · ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES · PI MEULEMAN, WOUTER · 2020 to 2024
$1.8M
NHGRI NIH HHS R35 HG011317NHGRI NIH HHS U54 HG007010NHGRI NIH HHS UM1 HG009444
6 · The paper itself

Abstract

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits

Indexed as

Consensus SequenceDeoxyribonuclease IDNADNA FootprintingGenetics, PopulationGenome, HumanGenome-Wide Association StudyHumansModels, MolecularPolymorphism, Single NucleotideRegulatory Sequences, Nucleic AcidTranscription FactorsDeoxyribonuclease IDNATranscription Factors

Identifiers

PMID32728250
PMCPMC7410829
OpenAlexW3046196569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.