ArticleNature2020
A large-scale binding and functional map of human RNA-binding proteins.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 823 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
823citing papers in PubMed, 1 pooled it
63.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
823 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,325 citations in OpenAlex.
- (Re)defining the human chromatome: an integrated meta-analysis of localization, function, abundance, physical properties, and domain composition of chromatin proteins.Nucleic acids research · 2026Pooled it
- Visualization of RNA Structures and Functional Annotations Using ArcPlot.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Decoding RNA-protein interactions using high-throughput methods.RNA biology · 2026Review
- OGT regulates RNA-binding protein nucleocytoplasmic partitioning, but this fails in amyotrophic lateral sclerosis.iScience · 2026Article
- Comprehensive characterization of transposable element expression reveals regulatory circuitry and clinical implications in cancers.Science advances · 2026Article
- DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3' UTRs.Molecular cell · 2026Article
- dsRNAscan maps human dsRNAome, revealing conservation, intermolecular dsRNA, and correlates of ADAR dependency.Molecular cell · 2026Article
- PUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features.Cell genomics · 2026Article
- Halting translation by the letter with sequence-selective small molecules.Nature chemical biology · 2026Review
- Codon optimality predicts mRNA half-life but does not transfer to lncRNAs.Molecular genetics and genomics : MGG · 2026Article
- A Real-Data-Driven Framework for Evaluating Differential Transcript Usage Methods Across Long-Read Bulk, Single-Cell, and Spatial Transcriptomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Expanded Polyglycine Protein Aggregates Alter the RNA Splicing Profile into a Premature State Partially via Sequestering SF3B4.Neuroscience bulletin · 2026Article
- RAISE quantifies RNA binding protein activity via transcriptomic profiling.Nature communications · 2026Article
- The RNA-Binding Protein ELAVL4/HuD Promotes Stress-Associated Tumor Survival in Neuroendocrine Cancers.International journal of molecular sciences · 2026Review
- Review
- Spatial mapping of RNA turnover kinetics in the mouse brain.Nature neuroscience · 2026Article
- A gene set collection of human RBP target genes.Scientific data · 2026Article
- Review
- Subcellular localization of human long non-coding RNAs is an isoform-resolved property masked by gene-level analysis.Molecular genetics and genomics : MGG · 2026Article
- Massively parallel characterization of RNA G-quadruplex stability and molecular recognition.Nucleic acids research · 2026Article
763 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
39 authors at 4 institutions in 3 countries.
Eric L Van Nostrand *Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5188-0082
Peter Freese *Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gabriel A Pratt *Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Xiaofeng Wang *Institut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
Xintao Wei *Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT, USA.
Rui Xiao *Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Steven M BlueDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Jia-Yu ChenDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9449-9321
Neal A L CodyInstitut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
Daniel DominguezDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sara OlsonDepartment of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT, USA.
Balaji SundararamanDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-8559-1660
Lijun ZhanDepartment of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT, USA.
Cassandra BazileDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Louis Philip Benoit BouvretteInstitut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
Julie BergaletInstitut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
Michael O DuffDepartment of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT, USA.
Keri E GarciaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Chelsea Gelboin-BurkhartDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Myles HochmanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nicole J LambertDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hairi LiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Michael P McGurkDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Thai B NguyenDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Tsultrim PaldenDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ines RabanoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4826-4403
Shashank SatheDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Rebecca StantonDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Amanda SuDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ruth WangDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Brian A YeeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Bing ZhouDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2846-1813
Ashley L LouieDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Stefan AignerDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9511-3328
Xiang-Dong FuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. xdfu@ucsd.edu.ORCID http://orcid.org/0000-0001-5499-8732
Eric LécuyerInstitut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada. eric.lecuyer@ircm.qc.ca.
Christopher B BurgeProgram in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. cburge@mit.edu.ORCID http://orcid.org/0000-0001-9047-5648
Brenton R GraveleyDepartment of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT, USA. graveley@uchc.edu.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.
University of California San Diego · USMassachusetts Institute of Technology · USInstitute for Systems Biology · USMontreal Clinical Research Institute · CA
Funding
Comprhensive analysis of functional RNA elements encoded in the human genomeU54HG007005 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2012 to 2017
$12.5MFunctional RNA elements in the human genomeR01HG004659 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett, Eugene Wei-Ming Yeo · 2008 to 2026
$12.4MA Comprehensive Functional Map of Human Protein-RNA InteractionsU41HG009889 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R., YEO, EUGENE WEI-MING · 2018 to 2021
$9.4MGraduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6MRobust, high-throughput identification of RNA processing regulators and regulatory networks genome-wideR00HG009530 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI VAN NOSTRAND, ERIC LYMAN · 2020 to 2022
$747kRobust, high-throughput identification of RNA processing regulators and regulatory networks genome-wideK99HG009530 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VAN NOSTRAND, ERIC LYMAN · 2017 to 2018
$250kNHGRI NIH HHS K99 HG009530NHGRI NIH HHS R00 HG009530NHGRI NIH HHS R01 HG004659NHGRI NIH HHS U41 HG009889NHGRI NIH HHS U54 HG007005
Abstract
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome
Indexed as
Alternative SplicingBase SequenceBinding SitesCell LineChromatinDatabases, GeneticFemaleGene Knockdown TechniquesHumansIntracellular SpaceMaleProtein BindingRNA-Binding ProteinsRNA, MessengerSubstrate SpecificityTranscriptomeChromatinRNA-Binding ProteinsRNA, Messenger
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.