ArticleNature2020
Spatiotemporal DNA methylome dynamics of the developing mouse fetus.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 1 synthesis or guideline pooled it, 191 citations in OpenAlex.
- Translational toxicoepigenetic Meta-Analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead exposure in mouse and human offspring.Environment international · 2024Pooled it
- MultiDMPcaller: a one-stop software for detection and visualization of differentially methylated positions and regions.Bioinformatics (Oxford, England) · 2026Article
- Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina.Science advances · 2026Article
- Single-cell profiling of DNA methylation in autism spectrum disorder prefrontal cortex reveals distinct regulatory and aging signatures.Cell genomics · 2026Article
- Early postnatal DNA methylation dynamics define neuronal subtypes and are disrupted by MECP2 loss.bioRxiv : the preprint server for biology · 2026Article
- Organ-Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- The genetic basis for DNA methylation variation across tissues and development.Nature communications · 2026Article
- Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging.Cell reports · 2026Article
- Transcriptional competence defines the heterochromatin nucleating potential of isolated MSR units.Nature communications · 2026Article
- mist: a hierarchical Bayesian framework for detecting differential DNA methylation dynamics in single-cell data.Nature communications · 2026Article
- Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome.bioRxiv : the preprint server for biology · 2026Article
- A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Antecedent enhancer activity predicts future susceptibility to seizures in mice.Nature communications · 2026Article
- Roles of different methylation modifications in cardiovascular disease.Frontiers of medicine · 2025Review
- Multi-omic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potential.Communications biology · 2025Article
- Identifying key regulators in neuronal transdifferentiation by gene regulatory network analysis.PNAS nexus · 2025Article
- Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings.Nature cancer · 2025Article
- Article
- Single-cell DNA methylation analysis tool Amethyst resolves distinct non-CG methylation patterns in human astrocytes and oligodendrocytes.Communications biology · 2025Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 4 institutions in 1 country.
Yupeng HeGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Manoj HariharanGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
David U GorkinLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.
Diane E DickelEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-5497-6824
Chongyuan LuoGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Rosa G CastanonGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Joseph R NeryGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Ah Young LeeLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.
Yuan ZhaoBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.
Hui HuangLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.
Brian A WilliamsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Diane TroutDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Henry AmrheinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Rongxin FangBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.
Huaming ChenGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Bin LiLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-4130-7784
Len A PennacchioEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-8748-3732
Bing RenLudwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5435-1127
Joseph R EckerGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. ecker@salk.edu.ORCID http://orcid.org/0000-0001-5799-5895
Salk Institute for Biological Studies · USUniversity of California San Diego · USCalifornia Institute of Technology · USLawrence Berkeley National Laboratory · US
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TONY R. HUNTER · 1985 to 2026
$82.8MUCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4MCenter for Mammalian Regulatory GenomicsU54HG006997 · NHGRI · LUDWIG INSTITUTE FOR CANCER RES LTD · PI REN, BING · 2012 to 2016
$14.3MHoward Hughes Medical InstituteNCI NIH HHS P30 CA014195NHGRI NIH HHS U54 HG006997NIGMS NIH HHS K12 GM068524
Abstract
Cytosine DNA methylation is essential for mammalian development but understanding of its spatiotemporal distribution in the developing embryo remains limited
Indexed as
DNA MethylationEpigenomeAnimalsAnimals, NewbornChromatinDiseaseDown-RegulationEnhancer Elements, GeneticEpigenetic RepressionFemaleFetusGene SilencingHumansMiceMice, Inbred C57BLModels, AnimalChromatin
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.