Evidence map›Paper›PMID 32728217›Full record

ArticleNature2020

Index and biological spectrum of human DNase I hypersensitive sites.

Wouter Meuleman, Alexander Muratov, Eric Rynes, Jessica Halow, Kristen Lee, Daniel Bates, Morgan Diegel, Douglas Dunn, Fidencio Neri, Athanasios Teodosiadis and 10 more

Abstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 213 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

213 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Article
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  12. Synthetic Regulatory Genomics.Annual review of genomics and human genetics · 2026
    Review
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  17. Review
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153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Wouter MeulemanAltius Institute for Biomedical Sciences, Seattle, WA, USA. wouter@meuleman.org.ORCID http://orcid.org/0000-0002-1196-5401
Alexander MuratovAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Eric RynesAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Jessica HalowAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Kristen LeeAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Daniel BatesAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Morgan DiegelAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Douglas DunnAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Fidencio NeriAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Athanasios TeodosiadisAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Alex ReynoldsAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Eric HaugenAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Jemma NelsonAltius Institute for Biomedical Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2846-2007
Audra JohnsonAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Mark FrerkerAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Michael BuckleyAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Richard SandstromAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Jeff VierstraAltius Institute for Biomedical Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6406-8563
Rajinder KaulAltius Institute for Biomedical Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7895-9284
John StamatoyannopoulosAltius Institute for Biomedical Sciences, Seattle, WA, USA. jstam@altius.org.ORCID http://orcid.org/0000-0002-2664-5769

Funding

ENCODE Mapping Center-A Comprehensive Catalog of DNase I Hypersensitive SitesUM1HG009444 · NHGRI · ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES · PI STAMATOYANNOPOULOS, JOHN A · 2017 to 2021
$15.9M
A Comprehensive Catalog of Dnasel Hypersensitive SitesU54HG007010 · NHGRI · UNIVERSITY OF WASHINGTON · PI STAMATOYANNOPOULOS, JOHN A · 2012 to 2016
$12.4M
Elucidation of the organizing principles of the regulatory genome through large-scale data integrationR35HG011317 · NHGRI · ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES · PI MEULEMAN, WOUTER · 2020 to 2024
$1.8M
NHGRI NIH HHS R35 HG011317NHGRI NIH HHS U54 HG007010NHGRI NIH HHS UM1 HG009444
6 · The paper itself

Abstract

DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA

Indexed as

Molecular Sequence AnnotationChromatinDeoxyribonuclease IDNAGene Expression RegulationGenesGenome, HumanHumansPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidChromatinDeoxyribonuclease IDNA

Identifiers

PMID32728217
PMCPMC7422677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.