ArticleScientific reports2020
Risk factors and associated outcomes of ventilator-associated events developed in 28 days among sepsis patients admitted to intensive care unit.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05556694 (Association Between Cumulative Fluids Balance and Ventilator Associated Events in Critically Ill Patients), which is not on this map. Cited by 16 papers.
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The trial behind it
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Association Between Cumulative Fluids Balance and Ventilator Associated Events in Critically Ill Patients: a Prospective Cohort Study
Who cites it
16 citing papers in PubMed.
- Epidemiology of ventilator associated events in intubated patients: a multicenter observational study.BMC infectious diseases · 2025Observational
- A reappraisal of association between ventilator-associated events and mortality among critically ill patients using marginal structural model: multicenter observational study.Intensive care medicine · 2025Observational
- Review
- Development and Validation of a Prediction Model for Respiratory Failure in Patients With Sepsis-Associated Acute Kidney Injury (SA-AKI) Within 48 Hours of Admission.Emergency medicine international · 2025Article
- Development and validation of a predictive model for invasive ventilation risk within 48 hours of admission in patients with early sepsis-associated acute kidney injury.Frontiers in medicine · 2025Article
- Enhancing ICU Outcomes Through Intelligent Monitoring Systems: A Comparative Study on Ventilator-Associated Events.Journal of clinical medicine · 2024Article
- Article
- The ongoing challenge of ventilator-associated pneumonia: epidemiology, prevention, and risk factors for mortality in a secondary care hospital intensive care unit.Infection prevention in practice · 2023Article
- Ventilator-associated events: From surveillance to optimizing management.Journal of intensive medicine · 2023Review
- Predicting respiratory decompensation in mechanically ventilated adult ICU patients.Frontiers in physiology · 2023Article
- Association of Hypernatremia with Immune Profiles and Clinical Outcomes in Adult Intensive Care Unit Patients with Sepsis.Biomedicines · 2022Article
- Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation.Biomedical journal · 2022Article
- The Survival of Septic Patients with Compensated Liver Cirrhosis Is Not Inferior to That of Septic Patients without Liver Cirrhosis: A Propensity Score Matching Analysis.Journal of clinical medicine · 2022Article
- Impact of an Educational Intervention Aimed at Nursing Staff on Oral Hygiene Care on the Incidence of Ventilator-Associated Pneumonia in Adults Ventilated in Intensive Care Unit.Investigacion y educacion en enfermeria · 2021Article
- Application of Peak Glucose Range and Diabetes Status in Mortality Risk Stratification in Critically Ill Patients with Sepsis.Diagnostics (Basel, Switzerland) · 2021Article
- Impact of Body Mass Index on the Survival of Patients with Sepsis with Different Modified NUTRIC Scores.Nutrients · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesized that Ventilator-Associated Event (VAE) within 28 days upon admission to medical intensive care units (ICUs) can be a predictor for poor outcomes in sepsis patients. We aimed to determine the risk factors and associated outcomes of VAE. A total of 453 consecutive mechanically ventilated (MV) sepsis patients were enrolled. Of them, 136 patients had immune profile study. Early VAE (< 7-day MV, n = 33) was associated with a higher mortality (90 days: 81.8% vs. 23.0% [non-VAE], P < 0.01), while late VAE (developed between 7 and 28 days, n = 85) was associated with longer MV day (43.8 days vs. 23.3 days [non-VAE], P < 0.05). The 90-day Kaplan-Meier survival curves showed three lines that separate the groups (non-VAE, early VAE, and late VAE). Cox regression models with time-varying coefficient covariates (adjusted for the number of days from intubation to VAE development) confirmed that VAE which occurred within 28 days upon admission to the medical ICUs can be associated with higher 90-day mortality. The risk factors for VAE development include impaired immune response (lower human leukocyte antigen D-related expression, higher interleukin-10 expression) and sepsis progression with elevated SOFA score (especially in coagulation sub-score).
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