Evidence map›Paper›PMID 32727930›Full record

ArticleInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2020

Dual antibiotic prevention bundle is associated with decreased surgical site infections.

Michelle Kuznicki, Adrianne Mallen, Emily Clair McClung, Sharon E Robertson, Sarah Todd, David Boulware, Stacy Martin, Rod Quilitz, Roberto J Vargas, Sachin M Apte

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Michelle KuznickiGynecologic Oncology, Cleveland Clinic Foundation, Cleveland, Ohio, USA kuznicm@ccf.org.
Adrianne MallenGynecologic Oncology, University of South Florida, Tampa, Florida, USA.
Emily Clair McClungGynecologic Oncology, University of Arizona Arizona Health Sciences Center, Tucson, Arizona, USA.
Sharon E RobertsonGynecologic Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sarah ToddGynecologic Oncology, University of Louisville, Louisville, Kentucky, USA.
David BoulwareInfection Prevention, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA.
Stacy MartinInfection Prevention, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA.
Rod QuilitzPharmacy, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, United States.
Roberto J VargasGynecologic Oncology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Sachin M ApteGynecologic Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA.
Moffitt Cancer Center · USCleveland Clinic · USIndiana University – Purdue University Indianapolis · USUniversity of Arizona · USUniversity of Louisville · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

backgroundGynecologic oncology surgery is associated with a wide variation in surgical site infection risk. The optimal method for infection prevention in this heterogeneous population remains uncertain. STUDY

designA retrospective cohort study was performed to compare surgical site infection rates for patients undergoing hysterectomy over a 1-year period surrounding the implementation of an institutional infection prevention bundle. The bundle comprised pre-operative, intra-operative, and post-operative interventions including a dual-agent antibiotic surgical prophylaxis with cefazolin and metronidazole. Cohorts consisted of patients undergoing surgery during the 6 months prior to this intervention (pre-bundle) versus those undergoing surgery during the 6 months following the intervention (post-bundle). Secondary outcomes included length of stay, readmission rates, compliance measures, and infection microbiology. Data were compared with pre-specified one-sided exact test, Chi-square test, Fisher's exact test, or Kruskal-Wallis test as appropriate.

resultsA total of 358 patients were included (178 PRE, 180 POST). Median age was 58 (range 23-90) years. The post-bundle cohort had a 58% reduction in surgical site infection rate, 3.3% POST vs 7.9% PRE (-4.5%, 95% CI -9.3% to -0.2%, p=0.049) as well as reductions in organ space infection, 0.6% POST vs 4.5% PRE (-3.9%, 95% CI -7.2% to -0.7%, p=0.019), and readmission rates, 2.2% POST vs 6.7% PRE (-4.5%, 95% CI -8.7% to -0.2%, p=0.04). Gram-positive, Gram-negative, and anaerobic bacteria were all prevalent in surgical site infection cultures. There were no monomicrobial infections in post-cohort cultures (0% POST vs 58% PRE, p=0.04). No infections contained methicillin-resistant

conclusionImplementation of a dual antibiotic infection prevention bundle was associated with a 58% reduction in surgical site infection rate after hysterectomy in a surgically diverse gynecologic oncology practice.

Indexed as

AdultAgedAged, 80 and overAntibiotic ProphylaxisFemaleGynecologic Surgical ProceduresHumansMiddle AgedRetrospective StudiesSurgical Wound InfectionYoung Adultgynecologic surgical proceduresgynecologylaparotomypostoperative complicationssurgical wound infection

Identifiers

PMID32727930
PMCPMC7868167
OpenAlexW3046653644

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.