Evidence map›Paper›PMID 32727906›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

LRCH1 deficiency enhances LAT signalosome formation and CD8

Chang Liu, Xiaoyan Xu, Lei Han, Xiaopeng Wan, Lingming Zheng, Chunyang Li, Zhaohui Liao, Jun Xiao, Ruiyue Zhong, Xin Zheng and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Structure and Emerging Functions of LRCH Proteins in Leukocyte Biology.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Chang LiuCancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072 Shanghai, China.ORCID 0000-0001-6499-5172
Xiaoyan XuState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Lei HanState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Xiaopeng WanState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001 Harbin, China.
Lingming ZhengState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Chunyang LiState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Zhaohui LiaoDepartment of Immuno-cell Therapy, CARsgen Therapeutics Ltd., 200231 Shanghai, China.
Jun XiaoState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Ruiyue ZhongState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Xin ZhengState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Qiong WangState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China.
Zonghai LiDepartment of Immuno-cell Therapy, CARsgen Therapeutics Ltd., 200231 Shanghai, China.
Hualan ChenState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001 Harbin, China.
Bin WeiCancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072 Shanghai, China; weibinwhy@shu.edu.cn hongyanwang@sibcb.ac.cn.
Hongyan WangState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China; weibinwhy@shu.edu.cn hongyanwang@sibcb.ac.cn.
Center for Excellence in Molecular Cell Science · CNChinese Academy of Agricultural Sciences · CNShandong University · CNShanghai Cancer Institute · CNShanghai Jiao Tong University · CNShanghai University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD8

Indexed as

Signal TransductionAdaptor Proteins, Signal TransducingAnimalsCD8-Positive T-LymphocytesCell MovementCells, CulturedCytotoxicity, ImmunologicEndocytosisGRB2 Adaptor ProteinHumansImmunotherapy, AdoptiveInfectionsInterferon-gammaLung NeoplasmsLymphocyte ActivationMembrane ProteinsAdaptor Proteins, Signal TransducingGRB2 Adaptor ProteinGRB2 protein, humanIFNG protein, mouseInterferon-gammaLAT protein, humanLRCH1 protein, humanMembrane ProteinsMicrofilament ProteinsReceptors, Antigen, T-CellReceptors, Chimeric AntigenCD8+ T cellcytotoxicityLATLRCH1migration

Identifiers

PMID32727906
PMCPMC7431024
OpenAlexW3045789071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.