Evidence map›Paper›PMID 32727853›Full record

ArticleOpen heart2020

Role of the central autonomic nervous system intrinsic functional organisation and psychosocial factors in primary microvascular angina and Takotsubo syndrome.

Magdalena Maria Cattaneo, Emanuele Pravatà, Micol Provenzi, Marco Moccetti, Alain Kaelin, Isabella Sudano, Luigi Biasucci, Camilla Gallino, Costanzo Limoni, Carlo Calanchini and 3 more

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02759341 (Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02759341 nacompletednot on this map

Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: a Study on the Brain-heart Interactions in Two Orphan Cardiac Diseases.

TypeinterventionalSponsorOspedale San Giovanni BellinzonaRan2016 to 2017Enrolled50ConditionsTakotsubo Cardiomyopathy, Cardiac X Syndrome, Acute Myocardial InfarctionArmsManual for the Assessment and Documentation of Psychopathology (AMDP 8), Million Clinical Multiaxial Inventory 3 (MCMI-III), State-Trait Anxiety Inventory form Y (STAI-Y), SF-36 Health-Related Quality of Life, Blood oxygenation level dependent- functional Magnetic Resonance Imaging (BOLD-fMRI)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Magdalena Maria Cattaneo *Cardiovascular Research, Hospital of San Giovanni, Bellinzona, Switzerland cattaneo.magdalena@gmail.com.ORCID 0000-0001-5678-3460
Emanuele Pravatà *Neuroradiology, Neurocenter of Southern Switzerland, Lugano, Switzerland.
Micol ProvenziPsychology, Psycho-Educational Center, Stabio, Switzerland.
Marco MoccettiCardiology, Cardiocentro Ticino, Lugano, Switzerland.
Alain KaelinNeuroradiology, Neurocenter of Southern Switzerland, Lugano, Switzerland.
Isabella SudanoCardiology, University Heart Center, Zurich, Switzerland.
Luigi BiasucciCardiology, Catholic University of Sacred Heart, Rome, Italy.
Camilla GallinoCardiovascular Research, Hospital of San Giovanni, Bellinzona, Switzerland.
Costanzo LimoniBiostatistics, University of Applied Sciences and Arts of Southern Switzerland, Lugano, Switzerland.
Carlo CalanchiniPsychiatry, Hospital Malcantonese Castelrotto, Castelrotto, Switzerland.
Augusto Gallino *Cardiovascular Research, Hospital of San Giovanni, Bellinzona, Switzerland.
Filippo CreaCardiology, Catholic University of Sacred Heart, Rome, Italy.
Mattia Cattaneo *Cardiovascular Research, Hospital of San Giovanni, Bellinzona, Switzerland.
Laboratory for Biomedical Neurosciences · CHUniversità Cattolica del Sacro Cuore · ITOspedale San Giovanni Bellinzona · CHUniversity of Applied Sciences and Arts of Southern Switzerland · CHEpatocentro Ticino · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

objectiveDysfunctional central autonomic nervous system network (CAN) at rest may result in aberrant autonomic responses to psychosocial stressors. We hypothesised that patients with primary microvascular angina (MVA) or Takotsubo syndrome (TTS) would exhibit a peculiar functional organisation of the CAN, potentially associated with psychological patterns.

methodsPatients underwent a psychosocial evaluation: a clinical diagnostic interview, Millon Clinical Multiaxial Inventory III, State-Trait Anxiety Inventory form Y and Short Form 36 Health Survey (SF-36). The strength of intrinsic functional connectivity (FC) between various nodes of the CAN was investigated using cerebral resting state functional MRI (RS-fMRI).

resultsWe evaluated 50 (46 women) stable patients: 16 patients with MVA, 17 patients with TTS and 17 patients with previous acute myocardial infarction (AMI). Compared with AMI, patients with MVA showed a lower (higher impairment) SF-36 Body-Pain score (p 0.046) and a higher SF-36 Mental-Health score (p 0.039). Patients with TTS showed the strongest FC between two nodes of the CAN (sympathetic midcingulate cortex and parasympathetic primary motor area) (F 6.25, p 0.005) using RS-fMRI.

conclusionsThe study implements an innovative collaborative research among cardiologists, neuroscientists and psychiatrists ('Neuro-psycho-heart Team'). MVA showed a discrepancy between the highest level of self-reported body pain and the best mental health score, which might suggest a mechanism of somatisation. TTS exhibited an increased functional integration between two areas of the CAN involved in interoceptive pain awareness and negative emotional status. We implemented an innovative research collaboration among cardiologists, neuroscientists and psychiatrists. These data are hypothesis generating and suggest potential prospective investigations on pathophysiology and implementation of psychotherapy and stress-reducing techniques as therapeutic strategies. TRIAL REGISTRATION NUMBER: NCT02759341.

Indexed as

Psychosocial FunctioningAgedAutonomic Nervous SystemBrain MappingCerebral CortexCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMental HealthMicrovascular AnginaNeuropsychological TestsPain PerceptionProspective StudiesStress, Psychologicalautonomic regulationcardiomyopathy apicalendothelial functionmicrovascularsyndrome X

Identifiers

PMID32727853
PMCPMC7394146
OpenAlexW3046637255

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.