Evidence map›Paper›PMID 32727742›Full record

ArticleBMJ open respiratory research2020

Nasopharyngeal density of respiratory viruses in childhood pneumonia in a highly vaccinated setting: findings from a case-control study.

Mejbah Uddin Bhuiyan, Tom Snelling, Chisha Sikazwe, Jurissa Lang, Meredith Borland, Andrew Martin, Peter Richmond, Adam Jaffe, David Smith, Christopher Blyth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Mejbah Uddin BhuiyanWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia mejbah.bhuiyan@telethonkids.org.au.ORCID http://orcid.org/0000-0002-8274-6265
Tom SnellingWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia.
Chisha SikazwePathWest Laboratory Medical WA, Nedlands, Western Australia, Australia.
Jurissa LangPathWest Laboratory Medical WA, Nedlands, Western Australia, Australia.
Meredith BorlandSchool of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Andrew MartinDepartment of General Paediatrics, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Peter RichmondSchool of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Adam JaffeSchool of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
David SmithPathWest Laboratory Medical WA, Nedlands, Western Australia, Australia.
Christopher BlythSchool of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
The University of Western Australia · AUPathwest Laboratory Medicine · AUThe Kids Research Institute Australia · AUPrincess Margaret Hospital for Children · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetection of pneumonia-causing respiratory viruses in the nasopharynx of asymptomatic children has made their actual contribution to pneumonia unclear. We compared nasopharyngeal viral density between children with and without pneumonia to understand if viral density could be used to diagnose pneumonia.

methodsNasopharyngeal swabs (NPS) were collected from hospitalised pneumonia cases at Princess Margaret Hospital (PMH) and contemporaneous age-matched controls at PMH outpatient clinics and a local immunisation clinic in Perth, Australia. The density (copies/mL) of respiratory syncytial virus (RSV), influenza A virus (InfA), human metapneumovirus (HMPV) and rhinovirus in NPS was determined using quantitative PCR. Linear regression analysis was done to assess the trend between viral density and age in months. The association between viral density and disease status was examined using logistic regression. Area under receiver operating characteristic (AUROC) curves were assessed to determine optimal discriminatory viral density cut-offs.

resultsThrough May 2015 to October 2017, 230 pneumonia cases and 230 controls were enrolled. Median nasopharyngeal density for any respiratory virus was not substantially higher in cases than controls (p>0.05 for each). A decreasing density trend with increasing age was observed-the trend was statistically significant for RSV (regression coefficient -0.04, p=0.004) but not for other viruses. After adjusting for demographics and other viral densities, for every log

conclusionThe nasopharyngeal density of respiratory viruses was not significantly higher in children with pneumonia than those without; however, the odds of being a case increased with increased density for some viruses. The utility of viral density, alone, in defining pneumonia was limited.

Indexed as

AdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornInfluenza A virusLinear ModelsMaleMetapneumovirusNasopharynxPneumonia, ViralRespiratory Syncytial Virus, HumanRhinoviruspneumoniarespiratory infectionviral infection

Identifiers

PMID32727742
PMCPMC7394014
OpenAlexW3046044235

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.