Evidence map›Paper›PMID 32727701›Full record

ArticleClinical lymphoma, myeloma & leukemia2020

Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib.

Francine M Foss, Ami Rubinowitz, Marie L Landry, Iris Isufi, Lohith Gowda, Stuart Seropian, Sarah Perreault, Sheela V Shenoi

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Clinical lymphoma, myeloma & leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Immune reconstitution and severity of COVID-19 among hematopoietic cell transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2021
    Article
  9. Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francine M FossHematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT. Electronic address: francine.foss@yale.edu.
Ami RubinowitzYale School of Medicine, Radiology and Biomedical Imaging, New Haven, CT.
Marie L LandryDepartments of Laboratory Medicine and Medicine, Yale University School of Medicine, New Haven, CT.
Iris IsufiHematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT.
Lohith GowdaHematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT.
Stuart SeropianHematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT.
Sarah PerreaultDepartment of Pharmacy, Yale New Haven Hospital, New Haven, CT.
Sheela V ShenoiInfectious Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT.
Yale University · USYale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has a high death rate in patients with comorbidities or in an immunocompromised state. We report a mild and attenuated SARS CoV-2 infection in a patient who is 17 months post stem cell transplantation and maintained on the JAK/STAT inhibitor ruxolitinib, a proposed novel therapy for SARS CoV-2 pneumonia.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunocompromised HostLymphoma, T-CellMaleMiddle AgedNitrilesPandemicsPneumonia, ViralPyrazolesPyrimidinesNitrilesPyrazolesPyrimidinesruxolitinibAllogeneic stem cell transplantationCOVID-19Graft-versus-host diseaseImmunocompromisedJAK inhibitor

Identifiers

PMID32727701
PMCPMC7316063
OpenAlexW3037179430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.