Evidence map›Paper›PMID 32727565›Full record

ArticleBMC medical genomics2020

Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation.

Yi-Yun Chen, Ming-Jie Jiang, Ling Tian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

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  4. The emerging role of exosomes in radiotherapy.Cell communication and signaling : CCS · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Yi-Yun ChenShanghai Key Laboratory of Pancreatic Diseases & Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Science bldg. Rm 205, New Songjiang Rd No.650, Songjiang District, Shanghai, 201620, China.
Ming-Jie JiangShanghai Key Laboratory of Pancreatic Diseases & Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Science bldg. Rm 205, New Songjiang Rd No.650, Songjiang District, Shanghai, 201620, China.
Ling TianShanghai Key Laboratory of Pancreatic Diseases & Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Science bldg. Rm 205, New Songjiang Rd No.650, Songjiang District, Shanghai, 201620, China. TL09168@hotmail.com.
Shanghai First People's Hospital · CNShanghai Jiao Tong University · CNSongjiang District Central Hospital · CN

Funding

National Natural Science Foundation of China No. 81773073Natural Science Foundation of Shanghai No. 16ZR1427500
6 · The paper itself

Abstract

backgroundPancreatic cancer is one of the most malignant tumors. However, radiotherapy can lead to tumor recurrence, which is caused by the residual surviving cells repopulation stimulated by some molecular released from dying cells. Exosomes may mediate cell-cell communication and transfer kinds of signals from the dying cells to the surviving cells for stimulating tumor repopulation. Circular RNAs (circRNAs) may be one vital kind of exosomal cargos involving in modulating cancer cell repopulation.

methodsNext generation sequencing (NGS) and bioinformatics were performed to analyze and annotate the expression and function of exosome-derived circRNAs in pancreatic cancer cells after radiation. Four circRNAs were chosen for qRT-PCR analysis to validate the sequencing results.

resultsIn this study, 3580 circRNAs were annotated in literatures and circBase among 12,572 identified circRNAs. There were 196 filtered differentially expressed circRNAs (the up-regulation and down-regulation respectively is 182 and 14, fold change > 2, p-value < 0.05). Regulation of metabolic process and lysine degradation were the main enriched biological processes and pathway according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.

conclusionsThe hsa_circ_0002130-hsa_miR_4482-3p-NBN interaction network suggested potential sponging miRNA and target mRNA. Our results provided potential functions of circRNAs to explore molecular mechanisms and therapeutic targets in pancreatic cancer cell repopulation upon irradiation.

Indexed as

Biomarkers, TumorComputational BiologyGene Expression Regulation, NeoplasticHigh-Throughput Nucleotide SequencingHumansMicroRNAsPancreatic NeoplasmsPrognosisRNA, CircularRNA, MessengerSurvival RateTumor Cells, CulturedX-RaysBiomarkers, TumorMicroRNAsRNA, CircularRNA, MessengerCancer repopulationCircular RNAExosomeGene expression profilingIrradiationPancreatic cancer

Identifiers

PMID32727565
PMCPMC7391519
OpenAlexW3045570752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.