Evidence map›Paper›PMID 32727507›Full record

ArticleBMC cancer2020

Liquid-based cytology for the detection of cervical intraepithelial lesions in Jimma town, Ethiopia.

Getnet Tesfaw, Yesuf Ahmed, Lealem Gedefaw, Lamessa Dube, Samson Godu, Kirubel Eshetu, Mesfin Nigussie, Haftamu Hailekiros, Moses Joloba, Gelila Goba and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Getnet TesfawJimma University, School of Medical Laboratory Sciences, PO Box =378, Jimma, Ethiopia. gettesfaw2@gmail.com.ORCID http://orcid.org/0000-0002-0344-784X
Yesuf AhmedJimma University, Department of Obstetrics & Gynecology, Jimma, Ethiopia.
Lealem GedefawJimma University, School of Medical Laboratory Sciences, PO Box =378, Jimma, Ethiopia.
Lamessa DubeJimma University, Department of Epidemiology, Jimma, Ethiopia.
Samson GoduJimma University, Department of Obstetrics & Gynecology, Jimma, Ethiopia.
Kirubel EshetuInternational Clinical Laboratories, Addis Ababa, Ethiopia.
Mesfin NigussieInternational Clinical Laboratories, Addis Ababa, Ethiopia.
Haftamu HailekirosMekelle University, Department of Medical Microbiology and Immunology, Mekelle, Ethiopia.
Moses JolobaDepartment of Microbiology, Makerere University, Kampala, Uganda.
Gelila GobaDepartment of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, USA.
Alemseged AbdissaJimma University, School of Medical Laboratory Sciences, PO Box =378, Jimma, Ethiopia.
Jimma University · ETMakerere University · UGMekelle University · ETUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical cancer is the second leading type of female cancer in Ethiopia. Screening for cervical cancer is primarily conducted using visual inspection with 5% acetic acid (VIA). Liquid-based cytology (LBC) is not yet widely used in Ethiopia.

methodWomen aged 21-65 years were tested using LBC and VIA to detect cervical dysplasia. Logistic regression analysis was conducted to identify associated factors. Cohen's Kappa test was conducted to test agreement between LBC and VIA.

resultsForty-two percent (n = 188) of 448 participants were 31 to 40 years of age and only two participants were above 60. Of the 448 participants, 419 (93.5%) were tested with LBC, 294 (65.6%) VIA and 272 (60.7%) with both LBC and VIA. Among women screened using LBC, 305 (72.8%) were negative for intraepithelial lesion or malignancy (NILM), 97 (23.2%) had low-grade squamous intraepithelial lesion (LSIL) and 17 (4.1%) had high-grade squamous intraepithelial lesion (HSIL). Presence of cervical lesions was generally lower in younger and older women. Majority, 39 (40%) of women with LSIL and 10 (59%) with HSIL were 41-50 years of age. Women aged 51-60 were more likely to have abnormal intraepithelial lesions compared to women aged 21-30 (AOR = 20.9, 95% CI = [7.2-60.9], p = 0.00). Out of 47 (10.8%) HIV-positive women, 14 (32.56%) had intraepithelial lesions of which 10 (23.3%) and 4 (9.3%) had LSIL and HSIL, respectively. Among women screened with VIA, 18 (6.1%) were positive; among the 272 (60.7%) women screened using both LBC and VIA, 6 (2.2%) were positive on both LBC and VIA tests. The level of agreement between the two tests was weak at a statistically significant level (kappa value = 0.155, p = 0.006).

conclusionLBC demonstrated high rates of cervical squamous intra-epithelial lesions in our study. VIA was a less reliable predictor of cervical squamous intra-epithelial lesions than LBC. Evaluating diagnostic accuracy of both LBC and VIA against a histological endpoint should be completed before adopting either or both screening modalities.

Indexed as

Acetic AcidAdultAgedAge DistributionCross-Sectional StudiesEthiopiaFemaleHumansIndicators and ReagentsLiquid BiopsyMiddle AgedRisk FactorsSquamous Intraepithelial Lesions of the CervixUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsAcetic AcidIndicators and ReagentsCervical squamous intra-epithelial lesionsEthiopiaLBCLiquid-based cytologyVIA

Identifiers

PMID32727507
PMCPMC7391806
OpenAlexW3046693016

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.